A pair of the best offensive players in the league will be featured when Puka Nacua and the Los Angeles Rams (2-1) host Jonathan Taylor and the Indianapolis Colts (3-0) on Sunday, September 28, 2025.
The Colts’ defense ranks ninth in the NFL with 18.7 points surrendered per game, but they’ve been bolstered by their offense, which ranks second-best by accumulating 34.3 points per game. The Rams have been firing on all cylinders this year, as they rank fifth-best in total offense (363.7 yards per game) and fifth-best in total defense (268.3 yards allowed per game).
Watch Los Angeles Rams vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)
Colts vs Rams: Live streaming info, TV channel & game timeGame day: Sunday, September 28, 2025Game time: 4:05 p.m. ETLocation: Inglewood, CaliforniaStadium: SoFi StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch Los Angeles Rams vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)
Colts vs Rams betting lines
NFL odds courtesy of BetMGM. Odds updated Saturday at 8:19 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Rams (-3.5)Moneyline: Rams (-189), Colts (+157)Total: 49.5 points
Watch Los Angeles Rams vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)