The San Francisco 49ers (3-0) are monitoring 14 players on their injury report as they prepare for their Sunday, Sept. 28 game against the Jacksonville Jaguars (2-1) at Levi’s Stadium, which kicks off at 4:05 p.m. ET.
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49ers vs Jaguars TV channel & game infoGame day: Sunday, September 28, 2025Game time: 4:05 p.m. ETLocation: Santa Clara, CaliforniaStadium: Levi’s StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch San Francisco 49ers vs. Jacksonville Jaguars on Fubo! (Regional restrictions may apply)
49ers injury reportCJ West | DT (Out)Injury: ThumbPractice Status: Did Not Participate In Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 2 Tackles | 0 Interceptions | 0 Passes DefendedJordan Watkins | WR (Out)Injury: CalfPractice Status: Did Not Participate In PracticeJauan Jennings | WR (Questionable)Injury: AnklePractice Status: Limited Participation in Practice2025 Receiving Stats: 15 Targets | 7 Receptions | 105 Yards | 1 TouchdownConnor Colby | OG (Questionable)Injury: GroinPractice Status: Limited Participation in Practice2025 Season Stats: 1 Games PlayedRicky Pearsall | WR (Questionable)Injury: KneePractice Status: Limited Participation in Practice2025 Receiving Stats: 24 Targets | 16 Receptions | 281 Yards | 0 TouchdownsMac Jones | QB (Questionable)Injury: KneePractice Status: Limited Participation in Practice2025 Passing: 80-for-53 | 563 Yards | 4 Touchdowns | 1 InterceptionYetur Gross-Matos | DLInjury: KneePractice Status: Did Not Participate In Practice2025 Season Stats: 2 Games PlayedRenardo Green | CBInjury: NeckPractice Status: Did Not Participate In Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 13 Tackles | 0 Interceptions | 3 Passes DefendedKalia Davis | DLInjury: AnklePractice Status: Full Participation in PracticeBrock Purdy | QBInjury: ShoulderPractice Status: Full Participation in Practice2025 Passing: 35-for-26 | 277 Yards | 2 Touchdowns | 2 Interceptions2025 Rushing: 5 Attempts | 17 Yards | 0 TouchdownsChristian McCaffrey | RBInjury: NIR – RestPractice Status: Full Participation in Practice2025 Rushing: 52 Attempts | 176 Yards | 0 Touchdowns2025 Receiving Stats: 32 Targets | 25 Receptions | 213 Yards | 1 TouchdownTrent Williams | OTInjury: NIR – RestPractice Status: Full Participation in Practice2025 Season Stats: 2 Games PlayedMykel Williams | DEInjury: WristPractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 3.0 Tackles for Loss | 8 Tackles | 0 Interceptions | 0 Passes DefendedDeommodore Lenoir | DBInjury: IllnessPractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 2.0 Tackles for Loss | 9 Tackles | 0 Interceptions | 0 Passes Defended49ers insightsThe 49ers put up just 2.7 more points per game (19.7) than the Jaguars surrender (17.0).The Jaguars have a 2-0 record against the spread and a 2-0 record overall in games when they allow less than 19.7 points.San Francisco averages 69.0 more yards per game (361.0) than Jacksonville gives up per contest (292.0).49ers vs Jaguars odds
NFL odds courtesy of BetMGM. Odds updated Saturday at 9:29 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-3.5)Moneyline: 49ers (-187), Jaguars (+153)Total: 46.5 points
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