The San Francisco 49ers look to remain one of the league’s last remaining undefeated teams when they host the Jacksonville Jaguars in the late Sunday afternoon window.

The San Francisco 49ers likely don’t really care that they aren’t blowing any teams out of the water to start the season. They’ve already beat two division opponents and look to improve to 4-0 when they host the Jacksonville Jaguars on Sunday. That comes after they have missed a lot of starters on offense, including their most important in quarterback Brock Purdy. Purdy is returning to the lineup against the Jaguars, after missing two weeks with a toe injury. It’s going to be tough though for the 49ers on defense, as they lost Nick Bosa for the rest of the season with a knee injury. The Jaguars come into this matchup with a 2-1 record after a division win against the Houston Texans.

How to Watch Jacksonville Jaguars at San Francisco 49ers Today:

Game Date: Sunday, Sept. 28, 2025

Game Time: 4:05 p.m. ET

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TV: FOX

Location: Levi’s Stadium – Santa Clara, CA

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San Francisco eked out a victory against its division opponent last week, beating the Arizona Cardinals 16-15 last. The 49ers won on a walkoff 35-yard field goal by Eddy Pineiro. It was the first of two last-second field goals that Arizona has suffered, after losing on Thursday Night Football in the same fashion to the Seattle Seahawks. It was an unlikely victory for San Francisco, especially after losing Bosa. The 49ers lost their lead by giving up a safety with just 3:15 left in the game on a defensive holding call. Despite all the odds, San Francisco won with its backup quarterback Mac Jones, who threw for 284 yards, and a rookie kicker who hit three field goals. Can Purdy kick this offense into a higher gear and keep San Francisco’s record spotless?

Jacksonville is coming off a 17-10 win over the Houston Texans. Brian Thomas Jr. struggled in the game, dropping three passes, but came up huge when it mattered most. The second-year wide receiver hauled in a 46-yard pass from Trevor Lawrence to set up Travis Etienne to score on the next play for the winning touchdown with less than two minutes left. The Jags defense also forced three turnovers in the back-and-forth game. Expect another close game between these similarly matched teams in Santa Clara today.

What Time Is The NFL Game Between Jacksonville and San Francisco On?

The Jacksonville Jaguars at San Francisco 49ers game will take place on Sunday, Sept. 28, 2025 at 4:05 p.m. ET. Tune in and catch some great NFL action.

What Channel Is the Jacksonville Jaguars at San Francisco 49ers On?

Looking to watch this game? Fans can tune into FOX locally to see the action. Make sure you subscribe to Fubo now to watch this matchup, as well as numerous other sports leagues.

Live stream the Jacksonville Jaguars at San Francisco 49ers game on Fubo: Start watching now!

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