South Florida vs. Charlotte odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 9:26 p.m.
Moneyline (ML): South Florida -4762 (Bet $4762 to win $100) | Charlotte +1610 (Bet $100 to win $1610)Against the spread (ATS): South Florida -27 (-110) | Charlotte +27 (-110)Over/Under (O/U): 54.5 (O: -112 | U: -108)South Florida vs. Charlotte betting tips preview
The South Florida Bulls (3-1) take on a fellow AAC foe when they host the Charlotte 49ers (1-3) on Friday, October 3, 2025 at Raymond James Stadium. The game will air on ESPN2, with the kickoff at 7 p.m. ET. Below, we analyze BetMGM Sportsbook’s lines around South Florida vs. Charlotte odds, and make our expert college football picks and predictions.
The Bulls knocked off the South Carolina State Bulldogs 63-14 in their last outing. The 49ers’ most recent outing ended in a 28-17 loss to the Rice Owls. In that matchup with the Bulldogs, Byrum Brown had 236 yards on 14-of-20 passing (70.0%) for the Bulls, with four touchdowns and one interception. Samuel Franklin carried the ball four times for 91 yards (22.8 yards per carry) with two touchdowns on the ground. Chas Nimrod had four receptions for 119 yards (29.8 per catch) and two touchdowns against the Bulldogs. Grayson Loftis threw for 186 yards for the 49ers against the Owls, going 15-for-31 (48.4%) with one touchdown and no interceptions. In that matchup, Rod Gainey Jr. had an eight-carry, 51-yard game (6.4 yards per attempt). He also added one reception for one yard . Javen Nicholas caught five passes on eight targets for 93 yards (18.6 yards per reception), and scored one touchdown.
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South Florida vs. Charlotte picks and predictionsPrediction
South Florida 51, Charlotte -10
MoneylineMoneyline pick: South Florida -4762South Florida has been the moneyline favorite only one other time so far this season, a game they won.The Bulls have played as a moneyline favorite of -4762 or shorter in only one game this season, which they won.Charlotte has been listed as the underdog three times this season and has failed to win any of those games.The 49ers have not entered a game this season as a bigger underdog on the moneyline than the +1610 odds on them winning this game.Against the spreadATS pick: South Florida -27The Bulls have beaten the spread three times in four games.South Florida is unbeaten ATS (1-0) as a 27-point favorite or greater this year.The 49ers have one win against the spread this season.
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