The Las Vegas Raiders (1-3) visit the Indianapolis Colts (3-1) at Lucas Oil Stadium in Indianapolis for a Week 5 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, October 5, including live updated odds and injury report news.
Colts vs. Raiders live odds, moneyline, over/under
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Colts vs. Raiders picks against the spread
Jon Hoefling: Las Vegas Raiders (+7)
This feels like a trap game. There’s a reason the Colts only opened at -1.5 favorites. The Raiders will likely surprise people here.
Tyler Dragon: Indianapolis Colts (-7)
I expect the Colts to have a much better performance after so many self-inflicted errors in Los Angeles last week. Colts get back on track here against a reeling Raiders club.
Richard Morin: Indianapolis Colts (-7)
The Raiders just aren’t very good. But are the Colts good enough to win by more than a touchdown? I say yes.
Lorenzo Reyes: Las Vegas Raiders (+7)
The Colts have regressed to the mean after a hot start to the season. I think Indy wins this game, but seven points is too rich for me, especially since rookie Raiders running back Ashton Jeanty broke out last week.
Blake Schuster: Las Vegas Raiders (+7)
Indy wins, but the Raiders cover here. Las Vegas isn’t a bad team, per se, and the Colts don’t really run opponents out of the building (Miami in Week 1 notwithstanding).
Christopher Bumbaca: Indianapolis Colts (-7)
What a jump on this spread, which opened at -1.5 It’s been a chalky year and the Colts’ offense still looked good against a great Rams defense.
Colts vs. Raiders updated injury reportNFL Week 5 picks, predictions oddsUSA TODAY NFL picks against the spread standingsNameWeek 42025 RecordBlake Schuster10-5-134-27-3Jon Hoefling7-8-133-28-3Tyler Dragon8-7-133-28-3Lorenzo Reyes5-10-130-31-3Chris Bumbaca6-9-130-31-3Jordan MendozaN/A24-22-2Richard Morin9-6-19-6-1Super Bowl 60 updated odds