The San Francisco 49ers (3-1) are dealing with 12 players on their injury report heading into their Thursday, Oct. 2 matchup versus the Los Angeles Rams (3-1) at SoFi Stadium, which kicks off at 8:15 p.m. ET.
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49ers vs Rams TV channel & game infoGame day: Thursday, October 2, 2025Game time: 8:15 p.m. ETLocation: Inglewood, CaliforniaStadium: SoFi StadiumTV channel: Amazon Prime VideoLive stream: Watch on Fubo! (Regional restrictions may apply)Live stream: Watch on Amazon Prime!
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
49ers injury reportJordan Watkins | WR (Out)Injury: CalfPractice Status: Did Not Participate In PracticeBrock Purdy | QB (Out)Injury: ToePractice Status: Did Not Participate In Practice2025 Passing: 73-for-48 | 586 Yards | 4 Touchdowns | 4 InterceptionsRicky Pearsall | WR (Out)Injury: KneePractice Status: Did Not Participate In Practice2025 Receiving Stats: 29 Targets | 20 Receptions | 327 Yards | 0 TouchdownsJauan Jennings | WR (Out)Injury: AnklePractice Status: Did Not Participate In Practice2025 Receiving Stats: 19 Targets | 9 Receptions | 129 Yards | 1 TouchdownRobert Beal | DL (Out)Injury: AnklePractice Status: Did Not Participate In Practice2024 Defensive Performance: 0.0 Sacks | 0.0 Tackles for Loss | 11 Tackles | 0 Interceptions | 0 Passes DefendedCJ West | DT (Questionable)Injury: ThumbPractice Status: Limited Participation in Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 2 Tackles | 0 Interceptions | 0 Passes DefendedDee Winters | LBInjury: KneePractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 3.0 Tackles for Loss | 32 Tackles | 0 Interceptions | 2 Passes DefendedMykel Williams | DLInjury: WristPractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 3.0 Tackles for Loss | 10 Tackles | 0 Interceptions | 0 Passes DefendedColton McKivitz | OLInjury: CalfPractice Status: Full Participation in Practice2025 Season Stats: 1 Games PlayedMac Jones | QBInjury: KneePractice Status: Full Participation in Practice2025 Passing: 80-for-53 | 563 Yards | 4 Touchdowns | 1 InterceptionYetur Gross-Matos | DLInjury: KneePractice Status: Full Participation in PracticeRenardo Green | CBInjury: NeckPractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 13 Tackles | 0 Interceptions | 3 Passes Defended49ers insightsThings have been going well for the 49ers on both sides of the ball, as they are averaging 368.0 total yards per game (fifth-best) and surrendering only 280.5 total yards per game (fifth-best).When San Francisco puts up more than 20.3 points, it is 1-1 against the spread and 1-1 overall.The 49ers’ pass offense has been excelling, accumulating 280.0 passing yards per game (second-best) this season. Defensively, they rank sixth by giving up 165.0 passing yards per game.San Francisco averages 83.5 more yards per game (368.0) than Los Angeles gives up (284.5).49ers vs Rams odds
NFL odds courtesy of BetMGM. Odds updated Wednesday at 9:29 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Rams (-7.5)Moneyline: Rams (-415), 49ers (+325)Total: 45.5 points
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