Who is the betting favorite in the Jaguars vs. Chiefs Week 5 Monday Night Football matchup?

The Jacksonville Jaguars are back at home in Week 5 for a Monday Night Football matchup with the Kansas City Chiefs.

The Jaguars will enter this game as home underdogs.

Both the Jaguars and Chiefs are winners of their last two games. Most recently, in Week 4, the Jaguars put on an impressive display of complementary football between all three phases to come away with the win over San Francisco.

The Chiefs, meanwhile, are now 2-2, which includes the Patrick Mahomes-led offense putting up 37 points last week on the Baltimore defense.

Jaguars vs. Chiefs betting odds, moneyline, and over/under

For the second time this season, the Jaguars will be wearing their Prowler throwback uniforms for this matchup.

Monday’s game will be the 17th time that the Jaguars and Chiefs have met. Kansas City currently holds the series lead at 10-6.

To see how the 2025 Jaguars and Chiefs stack up, you can find that here.

Also of note, the Jaguars could be without defensive end Travon Walker for this game. The latest report from ESPN says that Walker is considered week-to-week at this time with a wrist injury.

Jaguars vs. Chiefs game detailsWhat: Jaguars vs. Chiefs Week 5 matchup on Monday Night FootballWhen: Monday, Oct. 6thTime: 8:15 PM ETWhere: EverBank Stadium, Jacksonville, FLWhat channel is Jaguars vs. Chiefs on?

The game will be broadcast on ESPN on Monday night.