The Los Angeles Rams (3-1) will square off against their NFC West-rival, the San Francisco 49ers (3-1) in a matchup on Thursday, October 2, 2025 at SoFi Stadium. The 49ers will try to pull off an upset as 7.5-point underdogs. An over/under of 45.5 points has been set for the outing.
The 49ers lost to the Jacksonville Jaguars, 26-21, in their most recent contest.
Niners quarterback Brock Purdy was 22-for-38 for 309 yards, with two TDs and two INTs, versus the Jaguars.
Against the Indianapolis Colts in their most recent game, the Rams won 27-20.
49ers vs Rams betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Wednesday at 8:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Los Angeles (-7.5)Moneyline: Los Angeles (-415), San Francisco (+325)Total: 45.5 points49ers betting insightsIn away games last season, San Francisco had just one win against the spread and was 2-6 overall.The 49ers have put together a record of 2-2-0 against the spread this year.Last season, in eight away games, San Francisco hit the over six times.49ers games have gone over the total twice this year.49ers leadersPurdy: 586 PASS YDS / 293 YPG / 65.8% / 4 TD / 4 INT / 7 CAR / 30 RUSH YDS / 0 TDChristian McCaffrey: 69 CAR / 225 YDS / 56.3 YPG / 0 TD / 31 REC / 305 YDS / 76.3 YPG / 2 TDBrian Robinson Jr.: 22 CAR / 96 YDS / 24 YPG / 0 TDRicky Pearsall: 20 REC / 327 YDS / 81.8 YPG / 0 TDJauan Jennings: 9 REC / 129 YDS / 43 YPG / 1 TD49ers vs Rams game infoDate: Thursday, October 2, 2025Time: 8:15 p.m. ETCity: Inglewood, CaliforniaVenue: SoFi StadiumTV channel: Amazon Prime VideoLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Prime Video
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