The Tennessee Titans (0-4) are 7.5-point underdogs as they attempt to end their four-game losing streak in a matchup with the Arizona Cardinals (2-2) on Sunday, October 5, 2025 at State Farm Stadium.

Cardinals vs. Titans game infoGame day: Sunday, October 5, 2025Game time: 4:05 p.m. ETTV channel: CBSLocation: Glendale, ArizonaStadium: State Farm StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)Live stream: Watch this game on Paramount+ (Regional restrictions may apply)

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Cardinals vs. Titans odds & betting linesSpread favorite: Arizona (-7.5)Moneyline: Arizona (-426), Tennessee (+326)Total: 42.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Cardinals vs. Titans recent matchupsArizona holds the edge versus Tennessee in the last two matchups between the two teams, recording a 2-0 record.Arizona put up 50 points in those two matchups, with Tennessee putting up 20.Cardinals vs. Titans betting insightsArizona has two wins against the spread so far this season (2-2-0). The Cardinals won both of the games they have played when favored on the moneyline this season. Tennessee has won just one game against the spread this season (1-3-0). This is the fifth game this year the Titans are an underdog on the moneyline. They have lost each game.Cardinals scoring insightsWith an average of 20.7 points per game on offense and 20.3 points surrendered on defense over the last three games, the Cardinals rank 22nd and eighth, respectively, during that stretch.Titans scoring insightsThe Titans are worst in the NFL in points scored for the past three games (13.0 per game) and fourth-worst in points conceded (33.3).Cardinals injury reportCardinals:
Darius Robinson: Did Not Participate In Practice (Pectoral),
Will Johnson: Limited Participation in Practice (Groin),
Bilal Nichols: Limited Participation in Practice (Neck),
Zay Jones: Full Participation in Practice (Concussion),
Will Hernandez: Limited Participation in Practice (Knee),
Jon Gaines II: Limited Participation in Practice (Finger),
Simi Fehoko: Full Participation in Practice (Concussion),
Greg Dortch: Limited Participation in Practice (Collarbone),
Evan Brown: Limited Participation in Practice (Hamstring),
Kelvin Beachum: Full Participation in Practice (Rest)Titans injury reportTitans:
Kevin Zeitler: Limited Participation in Practice (Foot),
Kevin Winston Jr.: Limited Participation in Practice (Hamstring),
Tyjae Spears: Limited Participation in Practice (Ankle),
Jeffery Simmons: Full Participation in Practice (NIR – Rest),
Calvin Ridley: Did Not Participate In Practice (Knee),
Tony Pollard: Full Participation in Practice (NIR – Rest),
Bryce Oliver: Did Not Participate In Practice (Knee),
James Lynch: Limited Participation in Practice (Shoulder),
JC Latham: Did Not Participate In Practice (Hip),
Blake Hance: Did Not Participate In Practice (Shoulder),
Mike Brown: Did Not Participate In Practice (Knee)

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