Chiefs vs. Jaguars prediction, pick, odds for Monday's NFL Week 5 game

Chiefs vs. Jaguars odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 9:16 p.m.

Moneyline (ML): Kansas City -185 (Bet $185 to win $100) | Jacksonville +150 (Bet $100 to win $150)Against the spread (ATS): Kansas City -3.5 (-105) | Jacksonville +3.5 (-115)Over/Under (O/U): 45.5 (O: -110 | U: -110)Chiefs vs. Jaguars betting tips preview

Check out best bets for when the Kansas City Chiefs (2-2) and the Jacksonville Jaguars (3-1) play at EverBank Stadium on Monday, October 6, 2025.

The Chiefs last played against the Baltimore Ravens, and they prevailed 37-20. The Jaguars picked up a 26-21 victory last time out against the 49ers. Patrick Mahomes finished with 270 yards on 25-37 passing (67.6%) in the Chiefs’ last game, adding four touchdowns. Xavier Worthy ran for 38 yards on two attempts. He also hauled in five receptions for 83 yards Travis Kelce posted 48 yards on five receptions.

For the Jaguars in their last game, Trevor Lawrence completed 21 of 31 passing attempts (67.7%) and totaled 174 yards through the air, connecting on one touchdown pass. Travis Etienne had 19 rushing attempts and wound up with 124 yards and one touchdown. Brian Thomas ended the contest with five catches for 49 yards.

Watch Kansas City Chiefs vs. Jacksonville Jaguars on Fubo! (Regional restrictions may apply)

Chiefs vs. Jaguars key injuriesChiefsWR Marquise Brown (ankle) full participation in practiceDE Michael Danna (quad) full participation in practiceCB Kristian Fulton (ankle) limited participation in practiceQB Patrick Mahomes (groin) full participation in practiceDE Charles Omenihu (ankle) full participation in practiceWR JuJu Smith-Schuster (knee) full participation in practiceOT Jawaan Taylor (knee) full participation in practiceLS James Winchester (hamstring) full participation in practiceWR Xavier Worthy (shoulder) full participation in practiceJaguarsLB Yasir Abdullah (hamstring) did not participate in practiceWR Dyami Brown (shoulder) limited participation in practiceOL Ezra Cleveland (concussion) limited participation in practiceOG Chuma Edoga (knee) limited participation in practiceOL Anton Harrison (elbow) limited participation in practiceOL Patrick Mekari (knee) limited participation in practiceOL Wyatt Milum (knee) limited participation in practiceS Eric Murray (neck) limited participation in practiceRB Bhayshul Tuten (shoulder) limited participation in practiceDE Travon Walker (wrist) did not participate in practiceChiefs vs. Jaguars prediction

Jaguars 22, Chiefs 21

Moneyline pick: Jaguars +150Based on this game’s moneyline, the Chiefs’ implied win probability is 64.9%.Kansas City has been listed as the moneyline favorite just two other times so far this season, and they split the two games.The Chiefs have played as a moneyline favorite of -185 or shorter in just one game this season, which they won.Jacksonville has split the two games it has played as underdogs this season.The Jaguars have played as an underdog of +150 or more once this season and lost that game.Pick ATS: Jaguars (+3.5)Kansas City is 2-2-0 against the spread this season.The Chiefs covered the spread in their only game when favored by 3.5 points or more.In Jacksonville’s four games this season, it has three wins against the spread.The Jaguars have been underdogs by 3.5 points or more one time this year and have not covered the spread once.Pick OU: Under (45.5)The Chiefs and their opponents have scored a combined total of more than 45.5 points twice this season (in four games).The Jaguars and their opponents have scored more than 45.5 combined points twice this season.The two teams combine to score 48.3 points per game, 2.8 more points than this matchup’s total.Opponents of these two teams combine to average 37 points per game, 8.5 fewer points than this contest’s total.

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Chiefs vs. Jaguars prediction, pick, odds for Monday’s NFL Week 5 game

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