The San Francisco 49ers (4-1) visit the Tampa Bay Buccaneers (4-1) at Raymond James Stadium in Tampa for a Week 6 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, October 12, including live updated odds and injury report news.

Buccaneers vs. 49ers live odds, moneyline, over/under

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Buccaneers vs. 49ers picks against the spread

Jon Hoefling: Tampa Bay Buccaneers (-3)

Let’s be honest. San Francisco is not a great 4-1 team. They’ll get brought back down to Earth in this one.

Jordan Mendoza: San Francisco 49ers (+3)

Tampa Bay loves to play games all the way into the final minute. San Francisco looks like it’s finally over that Super Bowl hangover, and it should be able to put another game that goes down to the wire.

Tyler Dragon: Tampa Bay Buccaneers (-3)

The Bucs have found ways to win throughout the season. The 49ers are similiar despite dealing with injuries all around their roster.

Christopher Bumbaca: San Francisco 49ers (+3)

Two banged up NFC contenders. I am not in the business of picking against Baker Mayfield these days but I like that Kyle Shanahan is 6-3 against the spread after beating the Rams.

Lorenzo Reyes: Tampa Bay Buccaneers (-3)

This is a sneaky good game, whoever plays quarterback for the Niners. Still, Baker Mayfield has the Bucs offense rolling, and he has developed an excellent rapport with rookie receiver Emeka Egbuka. This one should be close, but I do like Tampa in the Florida heat.

Blake Schuster: Tampa Bay Buccaneers (-3)

Baker Mayfield is just incredible. I have no clue how he and the Bucs keep doing this, but I can’t fade them now.

Buccaneers vs. 49ers updated injury reportNFL Week 6 picks, predictions oddsUSA TODAY NFL picks against the spread standingsNameWeek 52025 RecordBlake Schuster7-741-34-3Jon Hoefling7-740-35-3Tyler Dragon6-839-36-3Chris Bumbaca6-836-39-3Lorenzo Reyes5-835-40-3Jordan MendozaN/A24-22-2Richard Morin8-617-12-1Super Bowl 60 updated odds