Theo Mackie on Cardinals’ ’embarrassing’ loss to Tennessee Titans
Theo Mackie discusses the collapse of the Arizona Cardinals in their last-second loss to the Tennessee Titans on Oct. 5, 2025.
The Arizona Cardinals and Indianapolis Colts play on Sunday, Oct. 12, at the Colts’ Lucas Oil Stadium in a game on the NFL Week 6 schedule.
Which team will win the NFL Week 6 game?
Check out these NFL Week 6 picks and NFL Week 6 predictions for the game, which can be seen at 10 a.m. MST on FOX (stream with FUBO).
The Colts are a 5.5-point favorite over the Cardinals in NFL Week 6 odds for the game, courtesy of BetMGM Sportsbook.
Indianapolis is -250 on the moneyline, while Arizona is +200. The over/under (point total) is set at 47.5 points.
NFL Week 6 picks: Eagles at Giants | Broncos vs Jets | Rams at Ravens | Cowboys at Panthers | Cardinals at Colts | Seahawks at Jaguars | Chargers at Dolphins | Browns at Steelers | Patriots at Saints | Titans at Raiders | 49ers at Buccaneers | Bengals at Packers | Lions at Chiefs | Bills at Falcons | Bears at Commanders | The Republic’s score predictions
Watch Cardinals at Colts live on FUBO (free trial)
Jeremy Cluff writes: “The Cardinals have lost three straight games on field goals as time has expired, including Emari Demercado and the team’s disastrous collapse against the Tennessee Titans in NFL Week 5. We don’t think Daniel Jones and company will need a late field goal to win this one.”
Bookies.com: Bet the Colts to cover vs Cardinals
Bill Speros writes: “The Cardinals hit the road for an early start but have yet to recover from their epic collapse against Tennessee.”
The site’s formula predicts that the Colts will win the NFL Week 6 game against the Cardinals.
ESPN: Colts have a 65.1% chance to beat Cardinals on Sunday
The site gives the Cardinals a 34.7% shot at winning the NFL Week 6 game, with the remaining percentage accounting for a tie.
Dimers: Cardinals 24, Colts 22
It writes: “After extensive simulations, our model gives the Cardinals a win probability of 57%, while the Colts have a win probability of 43%.”
Sportsnaut: Indianapolis Colts 24, Arizona Cardinals 20
Matt Johnson writes: “Two of the keys to beating the Indianapolis Colts are being able to take advantage of their run defense (4.5 yards per carry allowed) and having a No. 2 receiver who can exploit the secondary outside of Charvarius Ward. Unfortunately for the Arizona Cardinals, they have shortcomings in both areas. Indianapolis can protect Daniel Jones against this Cardinals’ pass rush, and we should see Michael Pittman Jr. and Josh Downs take advantage of an injury-depleted Arizona secondary. The Colts win a close one at home again.”
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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