Note: For previous coverage of this Week 6 TNF matchup, see our earlier Eagles vs. Giants preview.

The New York Giants will have a much-needed boost to their backfield for Thursday Night Football as rookie running back Tyrone Tracy Jr. returns from a shoulder injury that sidelined him for two games. Tracy’s comeback provides some relief for an offense that’s been battered by injuries, but the news isn’t all positive — wide receiver Darius Slayton has been ruled out with a hamstring strain after playing a major role in last week’s 26-14 loss to the Saints. With Malik Nabers already lost for the season, rookie quarterback Jaxson Dart will once again be working with a limited receiving corps, with Lil’Jordan Humphrey expected to be elevated from the practice squad.

The Giants’ offensive depth will be tested against an Eagles team that enters Thursday’s divisional matchup as 7.5-point favorites and heavy favorites in Dimers’ predictive model. Philadelphia’s ground attack led by Saquon Barkley and the efficient play of Jalen Hurts has powered one of the NFC’s most consistent teams through the first month of the season. Kickoff from MetLife Stadium is set for 8:15 p.m. ET, and the full betting preview below includes the latest odds, injury updates, and expert predictions for this Week 6 NFC East showdown.

Eagles vs. Giants betting preview

Explore the interactive widget below to see the latest spread, total, and moneyline betting odds and probabilities for the Eagles-Giants game at MetLife Stadium.

This prediction and best bet for Thursday’s NFL matchup between the Eagles and Giants is from Dimers.com, a trusted source for sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Eagles vs. Giants NFL game.

Teams: Philadelphia Eagles vs. New York GiantsDate: Thursday, October 9, 2025Kickoff: 8:15 p.m. ETLocation: MetLife StadiumNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL game between the Eagles and Giants.

Spread: Eagles -7.5 (-105), Giants +7.5 (-115)Moneyline: Eagles -390, Giants +310Total: Over/Under 40.5 (-110/-105)

The odds and lines presented here are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Eagles vs. Giants

Using state-of-the-art data analysis and advanced algorithms, the experts at Dimers have performed 10,000 simulations of Thursday’s Eagles vs. Giants matchup.

According to Dimers’ popular predictive analytics model, the Eagles are more likely to beat the Giants at MetLife Stadium. This prediction is based on the model giving the Eagles a 77% chance of winning the game.

Furthermore, Dimers predicts that the bookmakers have gotten it right and the Eagles and Giants each have a 50% chance of covering the spread, while the 40.5-point over/under is also considered an equal 50-50 chance of hitting.

These predictions and probabilities are correct at the time of publication but are subject to change.

Eagles vs. Giants best bet

Our top pick for the Eagles vs. Giants Week 6 NFL matchup is to bet on Under 40.5 points (-105).

This betting advice is based on detailed modeling and valuable wagering intelligence, designed to help you make more informed investments.

Score prediction for Eagles vs. Giants

Dimers’ predicted final score for the Philadelphia vs. NY Giants game on Thursday has the Eagles winning 23-16.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Thursday

NFL props are a great way to wager on Thursday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Eagles and Giants, along with projected player stats.

Philadelphia EaglesFirst touchdown scorer predictionsSaquon Barkley: 15.4% probabilityJalen Hurts: 14.2% probabilityA.J. Brown: 7.1% probabilityAnytime touchdown predictionsSaquon Barkley: 56.0% probabilityJalen Hurts: 53.1% probabilityA.J. Brown: 31.5% probabilityProjected box score leadersQB passing yards: Jalen Hurts, 200 yardsReceiving yards: A.J. Brown, 67 yardsRushing yards: Saquon Barkley, 88 yardsNew York GiantsFirst touchdown scorer predictionsCam Skattebo: 10.3% probabilityWan’Dale Robinson: 5.1% probabilityTyrone Tracy: 4.4% probabilityAnytime touchdown predictionsCam Skattebo: 41.0% probabilityWan’Dale Robinson: 23.0% probabilityTyrone Tracy: 20.4% probabilityProjected box score leadersQB passing yards: Jaxson Dart, 184 yardsReceiving yards: Wan’Dale Robinson, 50 yardsRushing yards: Cam Skattebo, 49 yardsNFL Week 6: Eagles vs. Giants

Get ready for Thursday’s game between the Eagles and Giants in Week 6 of the National Football League season at MetLife Stadium, which is scheduled to start at 8:15 p.m. ET. We emphasize that all of the NFL predictions and NFL best bets in this preview are derived from 10,000 data-driven simulations of the Eagles vs. Giants game, and they are correct at the time of publication. They are intended to help you make more informed choices when placing bets at online sportsbooks.

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