USC vs. Michigan odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 9:26 p.m.
Moneyline (ML): USC -135 (Bet $135 to win $100) | Michigan +113 (Bet $100 to win $113)Against the spread (ATS): USC -2.5 (-111) | Michigan +2.5 (-109)Over/Under (O/U): 57.5 (O: -110 | U: -110)USC vs. Michigan betting tips preview
Big Ten opponents meet when the USC Trojans (4-1) and the No. 15 Michigan Wolverines (4-1) play on Saturday, October 11, 2025 at Los Angeles Memorial Coliseum. The game will air on NBC, with the opening kick at 7:30 p.m. ET. Below, we analyze BetMGM Sportsbook’s lines around USC vs. Michigan odds, and make our expert college football picks and predictions.
The Trojans played the Illinois Fighting Illini in their most recent outing, losing 34-32. The Wolverines are coming off of a 24-10 win over the Wisconsin Badgers. Jayden Maiava threw for 364 yards, with two touchdowns and one interception on 30-of-43 passing (69.8%) for the Trojans in that matchup against the Fighting Illini. Waymond Jordan carried the ball 20 times for 94 yards (4.7 yards per carry) with two touchdowns on the ground. He also had two receptions for 12 yards. Makai Lemon had 151 yards on 11 catches (13.7 per reception) with two touchdowns in that game. Bryce Underwood notched 270 passing yards while going 19-for-28 with one touchdown and no interceptions for the Wolverines against the Badgers. Justice Haynes put together a 19-carry, 117-yard game (6.2 yards per attempt) with two touchdowns. Donaven McCulley caught six passes on seven targets for 112 yards (18.7 yards per reception), and scored one touchdown.
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USC vs. Michigan picks and predictionsPrediction
USC 31, Michigan 29
MoneylineMoneyline pick: USC -135USC has put together a 4-1 record in games it was favored on the moneyline (winning 80% of those games).The Trojans are 4-1 (winning 80% of their games) when playing as a moneyline favorite of -135 or shorter.Michigan lost the only game it has played as the underdog this season.The Wolverines have played as an underdog of +113 or more once this season and lost that game.Against the spreadATS pick: Michigan +2.5The Trojans have posted two wins against the spread this season.As at least a 2.5-point favorite, USC has two wins ATS (2-3).The Wolverines have two wins against the spread this year.Michigan has no wins ATS (0-1) as a 2.5-point underdog or more this season.
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