The Indianapolis Colts (4-1) host the Arizona Cardinals (2-3) at Lucas Oil Stadium in NFL Week 6 action. The Colts share the AFC South lead and the Cardinals could conceivably be 5-0. However, the Cardinals have lost three straight games, all on last-second field goals.
Week 3, 49ers 16, Cardinals 15: The Cardinals trailed the San Francisco 49ers by a touchdown early in the fourth quarter but took the lead on a safety with 3:15 remaining. Arizona punted on its ensuing possession and the Niners’ Eddy Pineiro kicked a 35-yard field goal with no time remaining.Week 4, Seahawks 23, Cardinals 20: Arizona rallied from a 14-point deficit to tie the Seattle Seahawks with 28 seconds to go. However, its ensuing kickoff fell short of the landing zone, and the Seahawks drove 26 yards for Jason Myers’ winning 52-yard field goal.Week 5, Titans 22, Cardinals 21: Arizona led the Tennessee Titans 21-6 early in the fourth quarter and Emari Demercado was on his way to a 72-yard touchdown run before dropping the ball short of the goal line. The ball rolled out of the back of the end zone, giving the Titans possession. Tennessee scored the game’s final 16 points — including on a play in which Tennessee QB Cam Ward threw an interception — and Joey Slye’s 29-yard field goal sealed the outcome.Colts vs. Cardinals key matchups
The 7th-year veteran and 2019 No. 1 overall draft pick has completed 68.3% of his passes for 962 yards, 6 touchdowns and 3 interceptions. He is also Arizona’s leading rusher with 173 yards (6.0 per) and 1 TD. Murray came away from Week 5 with a foot injury that kept him out of practice for at least one day. Former Colts QB Jacoby Brissett is the backup.
The 2nd-year player and son of the Indianapolis Colts receiving legend has 20 catches for a team-leading 306 yards (15.3 per) and 2 TDs. Indy’s No. 1 cornerback may have his hands full.
Sweat has 5 sacks, tied for 2nd in the NFL. Ageless defensive lineman Calais Campbell also has 3. Both will challenge the Colts offensive line, particularly the right tackle.
Will Kyler Murray play vs. Colts? Arizona Cardinals injury report vs. Indianapolis Colts for Oct. 12 in NFL Week 6?
Cardinals who did not practice Wednesday, Oct. 8: DL Darius Robinson (pectoral), QB Kyler Murray (foot), OL Kelvin Beachum (rest); limited participation: OL Evan Brown (hamstring), OL Will Hernandez (knee), CB Will Johnson (groin), WR Zay Jones (knee), CB Max Melton (hamstring), LB Cody Simon (knee), OL Jonah Williams (foot), LB Mack Wilson Sr. (ankle).
Are the Indianapolis Colts favored over the Arizona Cardinals on Sunday, Oct. 12? Indianapolis Colts-Arizona Cardinals betting odds for Sunday, Oct. 12, NFL Week 6via BetMGMFavorite: Colts by 7 pointsOver/under: 47 total pointsMoneyline: Colts -350, Cardinals +280ESPN’s matchup predictor gives the Colts a 63.7% chance of winning.What time does Indianapolis Colts-Arizona Cardinals NFL game start Sunday, Oct. 12, 2025? When is Cardinals-Colts NFL football game start time?
The Indianapolis Colts-Arizona Cardinals game is at 1 p.m. ET Sunday, Oct. 12, 2025, at Lucas Oil Stadium in Indianapolis.
Where to watch Arizona Cardinals vs Indianapolis Colts game on TV Sunday, Oct. 12, 2025? How to watch NFL Week 6 football game live
TV: Fox, with Kevin Kugler (play-by-play), Daryl Johnston (analysis) and Allison Williams (sideline reporting)
Watch Colts vs. Raiders in Week 6 on Fubo (free trial)
Thursday, Oct. 9: Philadelphia Eagles at New York Giants, 8:20 p.m. ET, Amazon (summary, box score)Sunday, Oct. 12: Denver Broncos vs. New York Jets in London, 9:30 a.m. ET, NFL Network (summary, box score)Sunday, Oct. 12: Los Angeles Rams at Baltimore Ravens, 1 p.m. ET, Fox (summary, box score)Sunday, Oct. 12: Dallas Cowboys at Carolina Panthers, 1 p.m., Fox (summary, box score)Sunday, Oct. 12: Arizona Cardinals at Indianapolis Colts, 1 p.m., Fox (summary, box score)Sunday, Oct. 12: Seattle Seahawks at Jacksonville Jaguars, 1 p.m., Fox (summary, box score)Sunday, Oct. 12: Los Angeles Chargers at Miami Dolphins, 1 p.m., CBS (summary, box score)Sunday, Oct. 12: Cleveland Browns at Pittsburgh Steelers, 1 p.m., CBS (summary, box score)Sunday, Oct. 12: San Francisco 49ers at Tampa Bay Buccaneers, 1 p.m., Fox (summary, box score)Sunday, Oct. 12: Tennessee Titans at Las Vegas Raiders, 4:05 p.m., Fox (summary, box score)Sunday, Oct. 12: Cincinnati Bengals at Green Bay Packers, 4:25 p.m., CBS (summary, box score)Sunday, Oct. 12: New England Patriots at New Orleans Saints, 4:25 p.m., CBS (summary, box score)Sunday, Oct. 12: Detroit Lions at Kansas City Chiefs, 8:20 p.m., NBC, Peacock, Telemundo (summary, box score)Monday, Oct. 13: Buffalo Bills at Atlanta Falcons, 7:15 p.m., ESPN (summary, box score)Monday, Oct. 13: Chicago Bears at Washington Commanders, 8:15 p.m., ABC (summary, box score)Bye week: Houston Texans, Minnesota Vikings
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Colts 2025 regular-season scheduleWeek 1: Indianapolis Colts 33, Miami Dolphins 8, box score, statsWeek 2: Colts 29, Denver Broncos 28, box score, statsWeek 3: Colts 41, Tennessee Titans 20, box score, statsWeek 4: Los Angeles Rams 27, Colts 20, box score, statsWeek 5: Colts 40, Las Vegas Raiders 6, box score, statsWeek 6: Sunday, Oct. 12, vs. Arizona Cardinals, 1 p.m., FoxWeek 7: Sunday, Oct. 19, at Los Angeles Chargers, 4:05 p.m., CBSWeek 8: Sunday, Oct. 26, vs. Tennessee Titans, 4:25 p.m., CBSWeek 9: Sunday, Nov. 2, at Pittsburgh Steelers, 1 p.m., CBSWeek 10: Sunday, Nov. 9, vs. Atlanta Falcons in Berlin, Germany, 9:30 a.m., NFL NetworkWeek 11: ByeWeek 12: Sunday, Nov. 23, at Kansas City Chiefs, 1 p.m., CBSWeek 13: Sunday, Nov. 30, vs. Houston Texans, 1 p.m., CBSWeek 14: Sunday, Dec. 7, at Jacksonville Jaguars, 1 p.m., CBSWeek 15: Sunday, Dec. 14, at Seattle Seahawks, 4:25 p.m., CBSWeek 16: Monday, Dec. 22, vs. San Francisco 49ers, 8:15 p.m., ESPN‘s “Monday Night Football”Week 17: Sunday, Dec. 28, vs. Jacksonville Jaguars, 1 p.m., FoxWeek 18: Date TBD, at Houston Texans, time TBD, TBD
Joel A. Erickson covers the Colts all season. Get more coverage on IndyStarTV and with the Colts Insider newsletter.