The Arizona Cardinals (2-3) have a projected difficult fight to halt their three-game losing streak as they are touchdown underdogs against the Indianapolis Colts (4-1) on Sunday, October 12, 2025 at Lucas Oil Stadium.

Colts vs. Cardinals game infoGame day: Sunday, October 12, 2025Game time: 1 p.m. ETTV channel: FOXLocation: Indianapolis, IndianaStadium: Lucas Oil StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)

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Colts vs. Cardinals odds & betting linesSpread favorite: Indianapolis (-7)Moneyline: Indianapolis (-357), Arizona (+283)Total: 46.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 2:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Colts vs. Cardinals recent matchupsArizona and Indianapolis have split their last two matchups (1-1).Indianapolis has had the upper hand scoring in those two matchups, scoring 35 points against Arizona’s 32.Colts vs. Cardinals betting insightsIndianapolis has four wins against the spread so far this season (4-1-0). The Colts have been listed as moneyline favorites three times this season, and they have recorded a 3-0 record in those outings. Arizona, in five games with a set spread so far this season, has gone 2-3-0 against the spread. The Cardinals have played a game as the underdog on the moneyline twice so far this season, and they lost both of the games.Colts scoring insightsThe Colts score 34.0 points per game at home, higher than their 30.5 average on the road.Defensively, Indianapolis is conceding 14.0 points per game at home, better than its 23.5 average away from home.On top of a top-five scoring offense over the last three contests (third-best with 33.7 points per game), the Colts also sport a top-five scoring defense (fourth-best with 17.7 points allowed per game) over that stretch.Cardinals scoring insightsAt home, the Cardinals are averaging more points (22.7) than away (17.5).Defensively, Arizona’s average at home, 22.3 points conceded, is worse than its average on the road, 14.5.On offense in their previous three games, the Cardinals are averaging 18.7 points, 25th in the NFL. Defensively, they are conceding 20.3, which places them eighth.Colts injury reportColts:
Grover Stewart: Full Participation in Practice (Biceps),
Braden Smith: Did Not Participate In Practice (Rest),
Alec Pierce: Full Participation in Practice (Concussion),
Kenny Moore II: Did Not Participate In Practice (Achilles),
Tyquan Lewis: Did Not Participate In Practice (Illness),
Tyler Goodson: Did Not Participate In Practice (Groin)Cardinals injury reportCardinals:
Will Johnson: Limited Participation in Practice (Groin),
Mack Wilson: Limited Participation in Practice (Ankle),
Jonah Williams: Limited Participation in Practice (Foot),
Cody Simon: Limited Participation in Practice (Knee),
Max Melton: Limited Participation in Practice (Hamstring),
Zay Jones: Limited Participation in Practice (Knee),
Will Hernandez: Limited Participation in Practice (Knee),
Evan Brown: Limited Participation in Practice (Hamstring),
Kelvin Beachum: Did Not Participate In Practice (Rest),
Kyler Murray: Did Not Participate In Practice (Foot),
Darius Robinson: Did Not Participate In Practice (Pectoral)

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