Oddsmakers give the Tampa Bay Buccaneers (4-1) the advantage on Sunday, October 12, 2025 against the San Francisco 49ers (4-1). Tampa Bay is favored by 3 points.

Buccaneers vs. 49ers game infoGame day: Sunday, October 12, 2025Game time: 4:25 p.m. ETTV channel: CBSLocation: Tampa, FloridaStadium: Raymond James StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)Live stream: Watch this game on Paramount+ (Regional restrictions may apply)

Watch Tampa Bay Buccaneers vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)

Buccaneers vs. 49ers odds & betting linesSpread favorite: Tampa Bay (-3)Moneyline: Tampa Bay (-161), San Francisco (+135)Total: 47.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Buccaneers vs. 49ers recent matchupsOver the past five matchups between Tampa Bay and San Francisco, the 49ers are 4-1.San Francisco outscored Tampa Bay 125-85 in the five head-to-head matchups between the two teams.Buccaneers vs. 49ers betting insightsTampa Bay, in five games with a spread this season, has gone 3-2-0 against the spread. In two games as a moneyline favorite, the Buccaneers have won both. San Francisco has three wins against the spread so far this season (3-2-0). The 49ers have played as the underdog on the moneyline one time so far this season and won.Buccaneers scoring insightsThe Buccaneers are averaging the same amount of points at home as on the road (27.0).Defensively, Tampa Bay is conceding 29.0 points per game at home, worse than its 24.7 average away from home.Offensively, the Buccaneers have been making things happen over the previous three games, putting up 30.7 points per game (fifth-best). They rank 27th over the last three games on defense (31.0 points per game allowed).49ers scoring insightsAt home, the 49ers score 18.5 points per game, which is lower than their 23.0 average away from home.On defense, San Francisco’s average at home, 20.5 points conceded, is higher than its average on the road, 19.0.In terms of points scored, including the past three games only, the 49ers are 21st in the league (21.0 per game). On the other side of the ball they are 11th in points conceded (21.3).Buccaneers injury reportBuccaneers:
Tristan Wirfs: Limited Participation in Practice (Knee),
Christian Izien: Limited Participation in Practice (Quad),
Jamel Dean: Full Participation in Practice (Hip),
Lavonte David: Limited Participation in Practice (Knee),
Benjamin Morrison: Did Not Participate In Practice (Hamstring),
Zyon McCollum: Did Not Participate In Practice (Thumb),
Teddy Bridgewater: Limited Participation in Practice (Shoulder),
Bucky Irving: Did Not Participate In Practice (Foot),
Chris Godwin: Did Not Participate In Practice (Shin),
Mike Evans: Did Not Participate In Practice (Hamstring)49ers injury report49ers:
Yetur Gross-Matos: Did Not Participate In Practice (Knee),
Alfred Collins: Limited Participation in Practice (Knee),
Robert Beal: Did Not Participate In Practice (Ankle),
Mykel Williams: Full Participation in Practice (Wrist),
Malik Mustapha: Full Participation in Practice (Knee),
Thomas Morstead: Full Participation in Practice (Back),
Kendrick Bourne: Full Participation in Practice (Rib),
CJ West: Limited Participation in Practice (Thumb),
Upton Stout: Limited Participation in Practice (Ankle),
Mac Jones: Limited Participation in Practice (Knee),
Kevin Givens: Limited Participation in Practice (Pectoral),
Kalia Davis: Limited Participation in Practice (Hand),
Trent Williams: Did Not Participate In Practice (Rest),
Jordan Watkins: Did Not Participate In Practice (Calf),
Brock Purdy: Did Not Participate In Practice (Toe),
Ricky Pearsall: Did Not Participate In Practice (Knee),
Christian McCaffrey: Full Participation in Practice (Rest),
Jauan Jennings: Limited Participation in Practice (Ankle)

Watch Tampa Bay Buccaneers vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)