The New England Patriots (3-2) visit the New Orleans Saints (1-4) at Caesars Superdome in New Orleans for a Week 6 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, October 12, including live updated odds and injury report news.
Saints vs. Patriots live odds, moneyline, over/under
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Saints vs. Patriots picks against the spread
Jon Hoefling: New England Patriots (-3.5)
So long as Rhamondre Stevenson doesn’t fumble 12 more times, the Patriots should be fine.
Jordan Mendoza: New England Patriots (-3.5)
Drake Maye is proving to finally be the guy in New England. He puts up another great performance to get the Patriots to 4-2.
Tyler Dragon: New England Patriots (-3.5)
Are the Patriots for real? A win versus Buffalo was a statement. Good teams beat the teams they are supposed to.
Christopher Bumbaca: New Orleans Saints (+3.5)
I don’t expect this to be a pretty one despite both teams riding high off emotional wins the week prior. I like New England to leave the “Big Easy” with a win but for the Saints to cover.
Lorenzo Reyes: New England Patriots (-3.5)
Drake Maye is coming into his own and looks to be a very promising quarterback. The Saints did pull off a win last week, but it was against the Giants. Even at home, I think the Saints will have a tough time matching New England’s scoring.
Blake Schuster: New England Patriots (-3.5)
Yeah, Drake Maye really is growing up fast. But I didn’t need to see that to fade New Orleans.
Saints vs. Patriots updated injury reportNFL Week 6 picks, predictions oddsUSA TODAY NFL picks against the spread standingsNameWeek 52025 RecordBlake Schuster7-741-34-3Jon Hoefling7-740-35-3Tyler Dragon6-839-36-3Chris Bumbaca6-836-39-3Lorenzo Reyes5-835-40-3Jordan MendozaN/A24-22-2Richard Morin8-617-12-1Super Bowl 60 updated odds