Based on our computer projections, the Tampa Bay Buccaneers will beat the San Francisco 49ers when the two teams match up at Raymond James Stadium on Sunday, Oct. 12, which begins at 4:25 p.m. ET. For our projections on the spead, point total, and final score, see the rest of the article below.
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Buccaneers vs. 49ers Game Info and TV Channel
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Buccaneers vs. 49ers Odds and Betting Info
Spread favorite: Buccaneers (-3)
Moneyline: Buccaneers (-162), 49ers (+136)
Total: 47.5 points
Buccaneers vs. 49ers Prediction
Pick ATS: 49ers (+3)
Pick OU: Under (47.5)
Prediction:
Buccaneers 24 – 49ers 23
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Buccaneers vs. 49ers Betting Insights
The Buccaneers have covered three times in five games with a spread this season.
The 49ers have covered three times in five games with a spread this season.
Tampa Bay has been favored by 3 points or more this season once, and failed to cover the spread.
San Francisco has covered the spread when playing as at least 3-point underdogs in its only opportunity this season.
Buccaneers games have gone over the point total three out of five times this season.
In 2025, three 49ers games have hit the over.
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