Indiana brings more than a paper-chase opportunity to Autzen Stadium this Saturday — it’s coming off an undefeated start, ranked No. 7, and now faces a Ducks squad also unbeaten and ranked No. 3 nationally. The stakes couldn’t be higher: this marks the first top-10 Big Ten matchup for Indiana since its resurgence, and a chance to knock off Northwestern’s new conference power on the road.
Oregon, meanwhile, enters with swagger and promise behind sophomore QB Dante Moore, who’s completed 74.6% of his passes on the year with 14 touchdowns and only 1 interception. The Ducks average 46.6 points per game, ranking among the nation’s most explosive offenses, and they’ll look to test Indiana’s secondary — possibly buoyed by the return of CB D’Angelo Ponds. Oddsmakers have Oregon as 7.5-point favorites, and Dimers’ simulations give the Ducks a 66% win probability heading into this high-stakes Big Ten clash.
Indiana vs. Oregon betting preview
Utilize the interactive widget below to discover the latest spread, total, and moneyline odds and probabilities for the Indiana-Oregon matchup at Autzen Stadium.
This prediction and best bet for Saturday’s college football matchup between Indiana and Oregon is from Dimers.com, a reliable source for sports betting predictions.
Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.
Game details
Key information on the Indiana vs. Oregon matchup, including where the game is and what time it kicks off.
Teams: Indiana vs. OregonDate: Saturday, October 11, 2025Kickoff: 3:30 p.m. ETLocation: Autzen StadiumNCAAF rankings: Updated AP Top 25College football news: Check the latest updates from the official NCAA football news siteOdds
The latest and best odds for the college football showdown between the Indiana and Oregon.
Spread: Indiana +7.5 (-115), Oregon -7.5 (-105)Moneyline: Indiana +230, Oregon -275Total: Over/Under 53.5 (-105/-110)
The odds and lines presented in this article are the best available from selected sports betting sites at the time of publication and are subject to change.
Expert prediction: Indiana vs. Oregon
Utilizing cutting-edge data analysis and computer power, the experts at Dimers have performed 10,000 simulations of Saturday’s Indiana vs. Oregon matchup.
According to Dimers’ independent predictive analytics model, Oregon is more likely to defeat Indiana at Autzen Stadium. This prediction is based on the model giving Oregon a 66% chance of winning the game.
Elsewhere on the betting board, Dimers predicts that Indiana (+7.5) has a 55% chance of covering the spread, while the over/under total of 53.5 points is considered an equal 50-50 chance of hitting.
As always, these predictions and probabilities are correct at the time of publication but are subject to potential changes.
Indiana vs. Oregon best bet
Our top pick for the Indiana vs. Oregon game on Saturday is to bet on Indiana moneyline (+230).
This expert betting advice is formulated through comprehensive modeling and valuable betting intelligence, designed to assist you in making more informed decisions.
While Oregon is more likely to win the game, according to Dimers, taking Indiana moneyline is the best option because of the 3.2% edge found when comparing Dimers’ data-driven probabilities to the betting odds.
Score prediction for Indiana vs. Oregon
Dimers’ predicted final score for the Indiana vs. Oregon game on Saturday has Oregon winning 29-23.
This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.
College football Week 7: Indiana vs. Oregon
Get ready for Saturday’s college football matchup between Indiana and Oregon at Autzen Stadium, which is scheduled to start at 3:30 p.m. ET. We emphasize that all of the college football predictions and college football best bets in this article are based on 10,000 data-driven simulations of the Indiana vs. Oregon matchup, and they are accurate at the time of publishing to help you make more informed choices when placing bets at online sportsbooks.
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