The Indianapolis Colts will learn their 2025 schedule with Wednesday night’s release from the NFL. The complete 18-week, 272-game regular season schedule along with all preseason dates will be set.

The Colts, who finished 8-9 last season, added defensive backs Charvarius Ward and Camryn Bynum, and quarterback Daniel Jones in free agency. They picked tight end Tyler Warren in the first round of the NFL Draft. Indianapolis lost offensive linemen Will Fries and Ryan Kelly, and edge rusher Dayo Odeyingbo in free agency.

Here’s what you should know about the NFL schedule release.

AFC South opponents, home and away: Houston Texans, Jacksonville Jaguars, Tennessee Titans

Home games: Denver Broncos, Las Vegas Raiders, Arizona Cardinals, San Francisco 49ers, Miami Dolphins, Atlanta Falcons.

Road games: Kansas City Chiefs, Los Angeles Chargers, Los Angeles Rams, Seattle Seahawks, Pittsburgh Steelers.

Colts strength of schedule

The Colts’ 2025 opponents had a .464 winning percentage the previous season, 24th in the 32-team league. Four of those games come against struggling AFC South foes Jacksonville and Tennessee.

Even with unsteady play under center last season, the Colts tied for the league lead with five wins in games decided by three or fewer points. Better quarterback play could yield more wins and perhaps a playoff berth.

Colts prime-time games

Without a premier quarterback, the Colts haven’t been a popular pick for night games. The vast majority of their games last season were 1 p.m. Sunday starts, though a November game against the Minnesota Vikings was flexed to a Monday night.

Only the Jaguars (6) have played fewer prime-time games at home over the last 10 years than the Colts (9). The Colts have played the 20th most total prime-time games in the last 10 years.

NFL prime-time results from 2015-24RkTeamGWLT1GNB55322302DAL53322103KAN49341504PHI48291905PIT44271706NWE43251807SEA42231818DEN39162309NYG39930010SFO392019011LAR382117012MIN371720013BAL362610014CHI351322015LAC351322016NOR341519017BUF322012018LVR311417019CIN281216020IND281018021TAM281018022NYJ27819023WAS271116024MIA26917025ARI251113126DET251510027HOU251213028TEN241212029ATL231310030CLE211110031CAR18711032JAX12570NFL home prime-time results from 2015-24RkTeamGWLT1GNB2820802PHI27171003SFO27141304DAL2617905KAN2619706SEA2516907PIT2316708LVR2113809LAR20146010ARI19711111NWE19127012LAC19811013DEN1899014MIN17116015NOR1789016NYG16511017CHI1578018NYJ15411019BAL15132020HOU1486021TAM14311022BUF1284023CIN1284024DET1275025WAS1266026CAR1156027CLE1183028ATL963029IND927030MIA936031TEN963032JAX6330

The early over-under, as set by Betmgm.com, has Indianapolis winning 7.5 games, two games behind the Houston Texans, even with the Jacksonville Jaguars and two ahead of the Tennessee Titans.

The Buffalo Bills, Baltimore Ravens, Kansas City Chiefs and Philadelphia Eagles are 11.5 wins. The Cleveland Browns trail the league at 4.5 wins.

What do Colts want to see on 2025 schedule?

There’s no way to take a game at Jacksonville — where they haven’t won since 2014 — off the schedule. And they have to play Week 1, which hasn’t treated them well, either. They haven’t won a season opener since 2013, though they tied the Houston Texans in 2022.

They’re going to host a game in Germany and make three trips to the West Coast (both Los Angeles teams and Seattle). At least they will pile up frequent flyer miles.

Looking to buy Colts tickets for 2025? We’ve got you covered. Season tickets, group tickets and single-game tickets are available at Colts.com.

Buy Indianapolis Colts tickets for 2025

When is Colts schedule release?

8 p.m. ET Wednesday, May 14, 2025