The Buffalo Bills (4-1) are less than a touchdown favorite (-4.5) on Monday, October 13, 2025 against the Atlanta Falcons (2-2).

Bills vs. Falcons game infoGame day: Monday, October 13, 2025Game time: 7:15 p.m. ETTV channel: ESPNLocation: Atlanta, GeorgiaStadium: Mercedes-Benz StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)

Watch Buffalo Bills vs. Atlanta Falcons on Fubo! (Regional restrictions may apply)

Bills vs. Falcons odds & betting linesSpread favorite: Buffalo (-4.5)Moneyline: Buffalo (-226), Atlanta (+184)Total: 50 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Bills vs. Falcons recent matchupsIn the last two meetings between the Bills and Falcons, Buffalo has gone 2-0.Buffalo outscored Atlanta 52-32 in those two head-to-head matchups.Bills vs. Falcons betting insightsBuffalo, through five games with a spread this season, has gone 2-3-0 against the spread. In four games as a moneyline favorite, the Bills have gone 3-1. Atlanta has won twice against the spread so far this season (2-2-0). The Falcons have played a game as the underdog on the moneyline two times so far this season, and they split the two games.Bills scoring insightsThe Bills are averaging more points at home (30.8) than away (30.0), but barely.On defense, Buffalo is allowing 25.8 points per game at home, more than its 10.0 average away from home.The Bills rank ninth in scoring offense (27.3 points per game) and 10th in scoring defense (21.0 points per game allowed) during their most recent three-game stretch.Falcons scoring insightsThe Falcons are 26th in the NFL in points scored for the past three games (18.7 per game) and 10th in points allowed (21.0).Bills injury reportBills:
Dorian Williams: Full Participation in Practice (Knee),
T.J. Sanders: Did Not Participate In Practice (Knee),
Curtis Samuel: Did Not Participate In Practice (Neck),
Taylor Rapp: Full Participation in Practice (Nose),
Ed Oliver: Limited Participation in Practice (Ankle),
Matt Milano: Did Not Participate In Practice (Pectoral),
Dalton Kincaid: Limited Participation in Practice (Oblique),
Damar Hamlin: Did Not Participate In Practice (Pectoral),
Dion Dawkins: Full Participation in Practice (Thumb)Falcons injury reportFalcons:
Clark Phillips III: Did Not Participate In Practice (Tricep),
Darnell Mooney: Did Not Participate In Practice (Hamstring),
Natrone Brooks: Limited Participation in Practice (Concussion),
A.J. Terrell: Limited Participation in Practice (Hamstring),
Khadarel Hodge: Limited Participation in Practice (Groin),
Ta’Quon Graham: Full Participation in Practice (Calf),
Nate Carter: Full Participation in Practice (Hamstring),
Xavier Watts: Limited Participation in Practice (Ankle),
LaCale London: Limited Participation in Practice (Tricep),
Billy Bowman: Limited Participation in Practice (Knee)

Watch Buffalo Bills vs. Atlanta Falcons on Fubo! (Regional restrictions may apply)