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Lamar Jackson will miss his second straight game for the Baltimore Ravens as the quarterback continues to be hampered by a hamstring injury.

Jackson missed his sixth straight practice on Friday, and the two-time NFL MVP will once again by replaced by backup Cooper Rush during the Ravens’ Week 6 matchup against the Los Angeles Rams. Baltimore has its bye in Week 7, which would give Jackson an extra week of recovery time in hopes that he could return for the Oct. 26 game against the Chicago Bears.

Rush went 14-for-20 for 179 yards, 0 touchdowns and 3 interceptions last week during a 44-10 loss to the Houston Texans, a defeat that dropped Baltimore to 1-4 on the season.

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Another regular starting quarterback who will sit out Week 6 is Brock Purdy of the San Francisco 49ers.

A toe injury has kept Purdy off the field, opening the door for Mac Jones to step in for another week after leading the 49ers to three wins in his three starts. Jones, however, is “questionable,” as he’s dealing with left knee and oblique injuries.

“[I’m] just getting treatment every day and working,” Jones said Thursday, via ESPN. “I feel confident and just working through it day by day. That’s all you can do.”

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Other notable Week 6 injuries:

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The Tampa Bay Buccaneers’ trio of running back Bucky Irving and wide receivers Mike Evans and Chris Godwin have been ruled out. Irving has been bothered by foot and shoulder injuries, while Evans has been suffering with a bad hamstring and Godwin has a fibula injury that is in a different location than the ankle injury he sustained last season. He is considered week-to-week and isn’t expected to land on injured reserve.

Arizona Cardinals quarterback Kyler Murray was back at practice on Friday after sitting out the past two days with a foot injury. Murray is officially “questionable” for Sunday’s game against the Indianapolis Colts. Jacoby Brissett is Murray’s backup.

As Noah Brown returned to practice, a quad injury has kept Washington Commanders wide receiver Terry McLaurin from the field this week, but head coach Dan Quinn expressed confidence he’ll be available Monday night against the Chicago Bears.

Tee Higgins and Andrei Iosivas could be Joe Flacco’s main receiving targets after the Cincinnati Bengals announced that Ja’Marr Chase is listed as “questionable” with an illness. Head coach Zac Taylor said the All-Pro receiver began feeling under the weather on Thursday night.

Week 6 byes: Houston Texans, Minnesota Vikings

Here’s the rest of the Week 6 injury report:

DENVER BRONCOS

OLB Jonah Elliss (ribs, shoulder): OUT

G Ben Powers (biceps): OUT

DL Malcolm Roach (calf): questionable

NEW YORK JETS

CB Michael Carter II (concussion): OUT

WR Allen Lazard (not injury related): OUT

CB Brandon Stephens (neck): questionable

LB Ja’Markis Weston (groin): questionable

LOS ANGELES RAMS

RT Rob Havenstein (ankle): doubtful

WR Tutu Atwell (hamstring): questionable

BALTIMORE RAVENS

QB Lamar Jackson (hamstring): OUT

WR Devontez Walker (oblique): OUT

LB Roquan Smith (hamstring): OUT

FB Patrick Ricard (calf): OUT

OT Emery Jones Jr. (shoulder): OUT

CB Chidobe Awuzie (hamstring): OUT

WR Zay Flowers (shoulder): questionable

SEATTLE SEAHAWKS

LB Derrick Hall (oblique): OUT

G/OT Josh Jones (ankle): OUT

S Julian Love (hamstring): doubtful

CB Devon Witherspoon (knee): doubtful

CB Riq Woolen (concussion): doubtful

JACKSONVILLE JAGUARS

TE Brenton Strange (hip): OUT

DALLAS COWBOYS

G Tyler Booker (ankle): OUT

WR CeeDee Lamb (ankle): OUT

LB Jack Sanborn (concussion): OUT

RB Miles Sanders (knee/ankle): OUT

WR KaVontae Turpin (foot): OUT

CB DaRon Bland (shoulder): questionable

CB Caelen Carson (knee): questionable

OT Ajani Cornelius (knee): questionable

CB Trevon Diggs (knee): questionable

DE Marshawn Kneeland (ankle): questionable

WR Jonathan Mingo (knee): questionable

G Tyler Smith (knee): questionable

CAROLINA PANTHERS

RB Chuba Hubbard (calf): OUT

OT Taylor Moton (elbow): OUT

DT Tershawn Wharton (toe): OUT

CB Akayleb Evans (hamstring): OUT

WR Jalen Coker (quad): questionable

TE Ja’Tavion Sanders (ankle): questionable

CB Mike Jackson (ribs): questionable

CB Chau Smith-Wade (chest): questionable

CLEVELAND BROWNS

DT Michael Hall Jr. (knee): OUT

PITTSBURGH STEELERS

WR Calvin Austin III (shoulder): OUT

CB Jalen Ramsey (hamstring): questionable

NEW ENGLAND PATRIOTS

RB Antonio Gibson (ACL): OUT

OLB Keion White (elbow): OUT

S Jaylinn Hawkins (hamstring): OUT

OLB Anfernee Jennings (ankle): OUT

CB Christian Gonzalez (hamstring): questionable

LB Marte Mapu (neck/hamstring): questionable

CB Charles Woods (knee): questionable

NEW ORLEANS SAINTS

CB Isaac Yiadom (hamstring): OUT

RB Alvin Kamara (ankle): questionable

DT John Ridgeway III (shoulder): questionable

LOS ANGELES CHARGERS

RB Omarion Hampton (ankle): OUT

WR Derius Davis (knee): OUT

RT Trey Pipkins (knee): OUT

DT Da’Shawn Hand (groin): OUT

FB Scott Matlock (ankle): questionable

WR Quentin Johnston (hamstring): questionable

RG Jamaree Salyer (knee): questionable

OLB Bud Dupree (hamstring): questionable

LB Denzel Perryman (ankle): questionable

MIAMI DOLPHINS

LB Tyrel Dodson (concussion): OUT

S Elijah Campbell (quad): OUT

CB Storm Duck (ankle): questionable

C Aaron Brewer (pectoral): questionable

ARIZONA CARDINALS

DL Darius Robinson (pectoral): OUT

QB Kyler Murray (foot): questionable

WR Zay Jones (knee): questionable

CB Max Melton (hamstring): questionable

LB Cody Simon (knee): questionable

LB Mack Wilson Sr. (ankle): questionable

P Blake Gillikin (back): questionable

INDIANAPOLIS COLTS

RB Tyler Goodson (groin): OUT

CB Kenny Moore (Achilles): OUT

TENNESSEE TITANS

WR Bryce Oliver (knee): OUT

G Blake Hance (shoulder): OUT

CB Marcus Harris (calf): OUT

K Joey Slye (right calf): OUT

WR Van Jefferson (ankle): questionable

OT JC Latham (hip): questionable

LAS VEGAS RAIDERS

TE Brock Bowers (knee): OUT

P AJ Cole (ankle): questionable

SAN FRANCISCO 49ERS

QB Brock Purdy (toe): OUT

WR Ricky Pearsall (knee): OUT

WR Jordan Watkins (calf): OUT

DE Yetur Gross-Matos (knee, hamstring): OUT

DT Kevin Givens (pectoral): OUT

DT Alfred Collins (knee): questionable

DT Kalia Davis (hand): questionable

WR Jauan Jennings (ankle, rib): questionable

QB Mac Jones (knee, oblique): questionable

S Malik Mustapha (knee): questionable

CB Upton Stout (ankle): questionable

TAMPA BAY BUCCANEERS

RB Bucky Irving (foot, shoulder): OUT

WR Mike Evans (hamstring): OUT

WR Chris Godwin (fibula): OUT

CB Zyon McCollum (thumb): OUT

CB Benjamin Morrison (hamstring): OUT

RB Josh Williams (concussion): OUT

S Christian Izien (quad): questionable

CINCINNATI BENGALS

DE Shemar Stewart (ankle): doubtful

WR Ja’Marr Chase (illness): questionable

LG Dylan Fairchild (knee): questionable

C Matt Lee (knee): questionable

RG Lucas Patrick (calf): questionable

GREEN BAY PACKERS

WR Christian Watson (knee): OUT

DETROIT LIONS

CB Terrion Arnold (shoulder): OUT

LB Zach Cunningham (hamstring): OUT

DL Alim McNeill (knee): OUT

RB Sione Vaki (groin): OUT

DB Brian Branch (ankle): questionable

T Taylor Decker (shoulder): questionable

S Kerby Joseph (knee): questionable

DB Avonte Maddox (hamstring): questionable

OL Giovanni Manu (knee): questionable

WR Kalif Raymond (neck): questionable

KANSAS CITY CHIEFS

No injury designations reported

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