Arizona (2-3) rides a three-game losing streak into a matchup with Indianapolis (4-1) on Sunday, October 12, 2025 at Lucas Oil Stadium. The Colts are significant favorites in this one, with the spread sitting at 7 points. The over/under is set at 47.5 in the outing.
The Cardinals‘ most recent game was against the Tennessee Titans, and they lost by a score of 22-21.
In that game against the Titans, Cards quarterback Kyler Murray completed 23 of 31 passes for 220 yards, with no touchdowns and no interceptions.
Last time around, the Colts defeated the Las Vegas Raiders, with 40-6 being the final score.
Cardinals vs Colts betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 4:59 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Indianapolis (-7)Moneyline: Indianapolis (-346), Arizona (+274)Total: 47.5 pointsCardinals betting insightsLast year on the road, Arizona was 5-3 against the spread and 2-6 overall.The Cardinals have gone 2-3-0 against the spread this season.Arizona was unbeaten ATS (1-0) as 7-point underdogs or more away from home.In eight away games last year, Arizona hit the over three times.Games involving the Cardinals have hit the over twice this year.Cardinals leadersMurray: 962 PASS YDS / 192.4 YPG / 68.3% / 6 TD / 3 INT / 29 CAR / 173 RUSH YDS / 1 TDEmari Demercado: 7 CAR / 89 YDS / 22.3 YPG / 0 TD / 2 REC / 13 YDS / 3.3 YPG / 1 TDMarvin Harrison Jr.: 20 REC / 306 YDS / 61.2 YPG / 2 TDTrey McBride: 29 REC / 275 YDS / 55.0 YPG / 1 TDElijah Higgins: 6 REC / 65 YDS / 13.0 YPG / 0 TDCardinals vs Colts game infoDate: Sunday, October 12, 2025Time: 1 p.m. ETCity: Indianapolis, IndianaVenue: Lucas Oil StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)
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