The Tennessee Titans (0-3) visit the Houston Texans (0-3) at NRG Stadium in Houston for a Week 4 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, September 28, including live updated odds and injury report news.
Texans vs. Titans live odds, moneyline, over/under
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Texans vs. Titans picks against the spread
Jon Hoefling: Tennessee Titans (+7)
Division opponents always play close games. With Brian Callahan already fighting for his job on Tennessee’s sideline, it would not be shocking to see a breakout game for Cam Ward and this Titans’ offense.
Blake Schuster: Houston Texans (-7)
I’m not sure which would feel more like an overreaction before Week 4: Giving up on the Texans or buying Cam Ward’s Titans. Ultimately I think Houston gets better first, especially with WR Christian Kirk getting back into rhythm. The Texans’ offensive line has been horrid, but Tennessee’s defense is giving up the third-most points per game. All that said, watch this game stay within a field goal until the end.
Tyler Dragon: Houston Texans (-7)
Houston we have a problem. C.J. Stroud and the offense have struggled thus far. But the Texans will get their first win against another winless team.
Richard Morin: Tennessee Titans (+7)
The Titans are better than people think and they’ll play Houston tough on the road.
Christopher Bumbaca: Houston Texans (-7)
I fear I’m getting off the Titans train at the wrong time but I am too impatient apparently. I totally bought the idea of a 0-3 C.J. Stroud and the Houston Texans. But I draw the line at 0-4.
Lorenzo Reyes: Tennessee Titans (+7)
At this point, even though I think the Texans have the more complete roster, I simply cannot back Houston, especially with a line this rich. The Texans rank dead last in scoring offense, generating just 12.7 points per game. Hard to see them covering 7.
Texans vs. Titans updated injury reportNFL Week 4 picks, predictions oddsUSA TODAY NFL picks against the spread standingsNameWeek 32025 RecordJon Hoefling10-626-20-2Tyler Dragon9-725-21-2Lorenzo Reyes9-725-21-2Chris Bumbaca7-924-22-2Jordan Mendoza9-724-22-2Blake Schuster8-824-22-2Super Bowl 60 updated odds