Week 6 MNF Prop Bets: Latest Odds, Best MNF Player Props for Bills at Falcons

There’s a natural crossover between fantasy football and NFL player prop bets, which offer a fun way to test your knowledge and prognostication skills. We’ll examine the three best wagers you should make for the NFL Week 6 Monday Night Football Game 1 matchup between the Buffalo Bills and Atlanta Falcons.

All odds are from DraftKings Sportsbook. DraftKings does not sponsor this content.

Bills QB Josh Allen Anytime TD (-110)

Atlanta’s run defense has been strong to open the year. Coming out of its Week 5 bye, the Falcons gave up only 357 offensive yards and one rushing TD to the running back position in the first month of place. The Bills’ James Cook could struggle to get it going, and there’s a reasonable chance Allen is the go-to guy inside the 5 this week, given the RPO threat he presents. Quarterbacks have scored once on the ground vs. Atlanta, which was Bryce Young in Week 2. All told, the positional foes haven’t posed anywhere near the rushing threat that is Allen.

Falcons PK John Parker Romo 2+ FGs (+103)

The points total for this one is 50, and it’s a fairly tight matchup on paper. Atlanta does a pretty solid job of slowing what Buffalo’s offense does well, and the Falcons get CB A.J. Terrell back on the field after two missed contests. In what should be a mostly back-and-forth affair, points could be at a premium, which lends to the Falcons accepting field goals rather than pushing their luck on fourth downs when in range. Kickers have attempted two-plus three-pointers in 60% of the matchups vs. the Bills in 2025, including each of the past two weeks.

Falcons WR Drake London Anytime TD (+140)

For as well as the Bills have handled enemy receivers thus far, the one area of weakness has been limiting touchdown grabs in relation to catches permitted … kinda important stuff. Despite being the ninth-best group at preventing WR receptions, a touchdown has occurred every 10.8 positional catches, which is the 11th-highest figure in the league. Five different receivers have scored, and three of those TDs were by the opposing team’s No. 1 wideout. With Darnell Mooney out, and limited reliable targets otherwise, expect Michael Penix Jr. to feed London all night long. Here’s to hoping one of them is good for six!

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This story was originally reported by Athlon Sports on Oct 12, 2025, where it first appeared in the Betting section. Add Athlon Sports as a Preferred Source by clicking here.

Week 6 MNF Prop Bets: Latest Odds, Best MNF Player Props for Bills at Falcons

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