The New Orleans Saints (1-4) will look to upset the New England Patriots (3-2) on Sunday, October 12, 2025 at Caesars Superdome. The Patriots are listed as favorites in this one, with the spread sitting at 3.5 points. The over/under is set at 45.5 in the contest.
The Patriots won against the Buffalo Bills in their most recent game, 23-20.
Against the Bills, Drake Maye completed 22 of 30 attempts for 273 yards, with no touchdowns and no interceptions, for the Pats.
Facing the New York Giants in their most recent contest, the Saints won 26-14.
Patriots vs Saints betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 1:55 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: New England (-3.5)Moneyline: New England (-192), New Orleans (+160)Total: 45.5 pointsPatriots betting insightsNew England was 4-5 against the spread, and 2-7 overall, away from home last season.The Patriots are 3-2-0 against the spread this season.In games they have played as 3.5-point favorites or more, the Patriots have a perfect ATS record of 1-0.Last year, in four of nine away games New England went over the total.This season, Patriots games have hit the over twice.Patriots leadersMaye: 1,261 PASS YDS / 252.2 YPG / 73.9% / 7 TD / 2 INT / 27 CAR / 110 RUSH YDS / 2 TDRhamondre Stevenson: 38 CAR / 139 YDS / 27.8 YPG / 2 TD / 13 REC / 154 YDS / 30.8 YPG / 0 TDTreVeyon Henderson: 32 CAR / 121 YDS / 24.2 YPG / 1 TD / 15 REC / 90 YDS / 18 YPG / 0 TDStefon Diggs: 29 REC / 359 YDS / 71.8 YPG / 0 TDHunter Henry: 17 REC / 250 YDS / 50 YPG / 3 TDKayshon Boutte: 13 REC / 208 YDS / 41.6 YPG / 1 TDPatriots vs Saints game infoDate: Sunday, October 12, 2025Time: 1 p.m. ETCity: New Orleans, LouisianaVenue: Caesars SuperdomeTV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Paramount+ (Regional restrictions may apply)
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