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The Tampa Bay Buccaneers (4-1) will host the San Francisco 49ers (4-1) in Week 6. Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, specifically regarding QB Baker Mayfield.

Is Baker Mayfield Playing in Week 6?

Mayfield is not on the injury report and will be good to go on Sunday.

We’ll continue to monitor the Buccaneers’ injury report leading up to kickoff for any changes. You can also visit and bookmark our Fantasy News Tracker for the latest updates.

Should You Start or Sit Baker Mayfield in Week 6?

We give Matthew Stafford the title of “WR King Maker” and he’s earned it. He’s got the Calvin Johnson seasons in his back pocket along with the Cooper Kupp historic campaign and is now leading the Puka Nacua march to top those marks.

But I’m not sure that Baker Mayfield is that far behind, and with him averaging 28.8 rushing yards per game in addition to elevating the talent around him, what’s not to like?

Tampa Bay’s lightning rod has yet to finish worse than QB13 this season and is anything but scared to exploit his advantages.

The primary advantage these days is, of course, rookie Emeka Egbuka. Mayfield is keenly aware that opponents are terrified of him down the field, and until they prove they have an answer, I fully expect him to continue to pick at that scab.

For the season, 44.7% of his throws to Egbuka have traveled 15+ yards in the air, a massive spike from his rate to the rest of his teammates (21.1%), and I’d say it’s working.

He faces a 49ers defense this season that has allowed 21+ fantasy points to a QB in each of their past two road games (big bad Spencer Rattler back in Week 2 and the aforementioned Stafford last Thursday night) and ranks 23rd in pressure rate.

I doubt he’s as efficient as he was in Sunday’s last-second win over the Seahawks (29-of-33, 11.5 yards per pass), but 65% complete with multiple touchdowns and 25-35 rushing yards? That’s what he gives us weekly, and I’m confident he gives us low-end QB1 numbers in a very interesting matchup that only gets more favorable if San Francisco gets some of their offensive firepower back.

Are you looking for start/sit advice for other players in your lineup? Read our Fantasy Football Start ‘Em, Sit ‘Em Cheat Sheet.

Mayfield’s Fantasy Points Projection in Week 6

Mayfield is projected to score 19.2 fantasy points in PPR formats.

We project Mayfield to throw for 268 yards and 1.8 passing touchdowns with 0.9 interceptions. Mayfield could also add 15 rushing yards and 0.1 rushing touchdowns on the ground.

Check out the free PFSN Fantasy Start-Sit Optimizer for the latest projections and advice for your lineups this week.

Week 6 Weather Impact: 49ers at Buccaneers

The forecast for kickoff is 85 degrees Fahrenheit with 17 mph winds. Moderate winds may affect deep passes and field goal attempts.