The Buffalo Bills (4-1) and Atlanta Falcons (2-2) meet in Week 6 on Monday Night Football. Kickoff from Mercedes-Benz Stadium in Atlanta, Georgia, is set for 7:15 p.m. ET (ESPN). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Falcons odds and make our expert NFL picks and predictions for the best bets.

The Bills suffered a surprising loss to the New England Patriots 23-20 last Sunday as an 8-point favorite as the Under (48.5) cashed. The loss was Buffalo’s first game this season in which it didn’t hit at least 30 points. The AFC East keaders are led by QB Josh Allen, who has 1,217 passing yards and 12 total touchdowns.

Atlanta had a Week 5 bye. The Falcons beat the Washington Commanders 34-27 at home in Week 4, covering as a 2.5-point favorite as the Over (43.5) hit. It has traded off winning and losing throughout its first 4 weeks, having gone 1-1 against the spread (ATS) at home. RB Bijan Robinson is the team’s most dangerous weapon, having 314 rushing yards through 4 games.

The Bills won 29-15 on Jan. 2, 2022, the last time these teams played, but the Falcons covered as a 14.5-point road underdog and lead the all-time series 7-6.

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Bills at Falcons odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 7:26 p.m. ET.

Moneyline (ML): Bills -210 (bet $210 to win $100) | Falcons +170 (bet $100 to win $170)Against the spread (ATS): Bills -4 (-110) | Falcons +4 (-110)Over/Under (O/U): 50 (O: -110 | U: -110)

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Bills at Falcons key injuries

Bills

TE Dalton Kincaid (oblique) questionableLB Matt Milano (pectoral) out

Falcons

WR Darnell Mooney (hamstring) outS Billy Bowman Jr. (triceps) questionableBills at Falcons picks and predictionsPrediction

Bills 27, Falcons 20

PASS.

Avoid this play. The Bills (-210) are too expensive to consider, while the Falcons (+170) have been too inconsistent to think they can pull off the upset.

BET BILLS -4 (-110).

The Falcons might have put up 34 points on the Commanders in Week 4, but they lost 30-0 to the Carolina Panthers the week prior. QB Michael Penix Jr. has 3 INTs and just a 62.4% completion rate.

With Buffalo ranking 10th in opponents’ completion percentage (64.66%), the Falcons may struggle to move the ball. At the same time, the Bills sit third in yards per game (395.8) and will find a way to get the ball in the end zone, as they have done all season.

Expect their offense to allow them to pull away and take BILLS -4 (-110).

BET UNDER 50 (-110).

Both of these teams rank first (Buffalo at 34:09) and second (Atlanta at 33:30) in average time of possession. These teams know how to keep drives alive and should drain the clock in doing so.

The Falcons are 1-3 O/U on the year, while the Bills are 0-1 O/U on the road. Buffalo has allowed 23 or fewer points in 4 of 5 games this season. Back UNDER 50 (-110).

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