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NFL Overreactions Week 6: New QBs enter MVP talk, Chiefs beat Lions

USA TODAY Sports’ Lorenzo Reyes ‘overreacts’ to some of the best games from Sunday’s Week 6 slate.

The Indianapolis Colts and Los Angeles Chargers play on Sunday, Oct. 19, at the Chargers’ SoFi Stadium in a game on the NFL Week 7 schedule.

Which team will win the NFL Week 7 game?

Check out these NFL Week 7 picks and NFL Week 7 predictions for the game, which can be seen at 1:05 p.m. MST on CBS (stream with FUBO).

The Chargers are a 1.5-point favorite over the Colts in NFL Week 7 odds for the game, courtesy of BetMGM Sportsbook.

Los Angeles is -125 on the moneyline, while Indianapolis is +105. The over/under (point total) is set at 48.5 points.

NFL Week 7 picks: Steelers at Bengals | Rams vs Jaguars | Saints at Bears | Dolphins at Browns | Raiders at Chiefs | Eagles at Vikings | Panthers at Jets | Patriots at Titans | Giants at Broncos | Colts at Chargers | Packers at Cardinals | Commanders at Cowboys | Falcons at 49ers | Buccaneers at Lions | Texans at Seahawks | The Republic’s predictions

Watch Colts at Chargers live on FUBO (free trial)

Jeremy Cluff writes: “In Week 4, the Colts fell to the Rams at SoFi Stadium, 27-20. Daniel Jones and Indianapolis get to return to that venue in Week 7 and will get a different, better result.”

Bookies.com: Bet the Colts on the moneyline vs Chargers

Bill Speros writes: “Speaking of potential playoff previews . . . the AFC South-leading Colts (5-1) and AFC West-leading Chargers (4-2) rest above the postseason Mendoza line. For now. Daniel Jones (like Baker Mayfield) continues to amaze after being discarded in a previous life. Both teams survived sloppy performances Sunday. The Chargers needed a last-minute drive to escape from Miami with a 29-27 win. The Colts find some running room against the Chargers defense this week. And that opens things up for Indiana Jones/Danny Dollars.”

The site’s formula predicts the Colts will win their Week 7 game against the Chargers.

ESPN: Chargers have a 51.3% chance to beat Colts on Sunday

The site gives the Colts a 48.3% shot at winning the NFL Week 7 game, with the remaining percentage accounting for a tie.

Dimers: Chargers 25, Colts 20

It writes: “After extensive simulations, our model gives the Colts a win probability of 29%, while the Chargers have a win probability of 71%.”

Sportsnaut: Indianapolis Colts 24, Los Angeles Chargers 17

Matt Johnson writes: “The Los Angeles Chargers have two big problems in this Week 7 draw versus the Indianapolis Colts. First, opponents have averaged 144.8 rush ypg and 5.2 yards per carry against Los Angeles in the last four games. Second, the Chargers’ defense really struggles at generating pressure without Khalil Mack. Those two issues together are a recipe for a loss to Daniel Jones and Jonathan Taylor, especially given how dominant the Colts’ offensive line has been this season.”

NFL’s highest paid players in 2025: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Highest paid NFL players: Overall | By position | By team

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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