Miami (FL) vs. Louisville odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 9:26 p.m.
Moneyline (ML): Miami (FL) -562 (Bet $562 to win $100) | Louisville +414 (Bet $100 to win $414)Against the spread (ATS): Miami (FL) -13.5 (-114) | Louisville +13.5 (-106)Over/Under (O/U): 51.5 (O: -113 | U: -107)Miami (FL) vs. Louisville betting tips preview
The No. 2 Miami Hurricanes (5-0) and the Louisville Cardinals (4-1) square off on Friday, October 17, 2025 at Hard Rock Stadium in a clash of ACC opponents. The contest will be broadcast on ESPN, with the kickoff at 7 p.m. ET. Below, we analyze BetMGM Sportsbook’s lines around Miami (FL) vs. Louisville odds, and make our expert college football picks and predictions.
The Hurricanes head into this matchup after a 28-22 win over the Florida State Seminoles in their last game. The Cardinals are coming off of a loss to the Virginia Cavaliers by the score of 30-27. In that matchup with the Seminoles, Carson Beck had 241 yards on 20-of-27 passing (74.1%) for the Canes, with four touchdowns and no interceptions. Mark Fletcher totaled 40 rushing yards on 12 carries (3.3 yards per carry). He also had one catch for eight yards. Malachi Toney had seven receptions for 107 yards (15.3 per catch) and two touchdowns against the Seminoles. Miller Moss’ showing for the Cards against the Cavaliers included 34-of-48 passing for 329 yards, two touchdowns and one interception. He rushed eight times for -38 yards and one touchdown. In that matchup, Isaac Brown had a 13-carry, 66-yard game (5.1 yards per attempt). He tacked on two receptions for six yards . Chris Bell collected 12 catches for 170 yards (on 14 targets), with two touchdowns.
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Miami (FL) vs. Louisville picks and predictionsPrediction
Miami (FL) 38, Louisville 13
MoneylineMoneyline pick: Miami (FL) -562Miami (FL) has been favored on the moneyline a total of four times this season, and it has won all of those games.The Hurricanes have played as a moneyline favorite of -562 or shorter in just two games this season, and they won both.Louisville has not played a game this season while listed as the underdog.The Cardinals have not entered a game this season as a bigger underdog on the moneyline than the +414 odds on them winning this game.Against the spreadATS pick: Miami (FL) -13.5Against the spread, the Hurricanes are 4-1-0 this year.Miami (FL) has won once ATS (1-1) as a 13.5-point or higher favorite this season.The Cardinals have posted one win against the spread this year.
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