The Los Angeles Chargers (4-2) are favored by only 1.5 points against the Indianapolis Colts (5-1) on Sunday, October 19, 2025.

Chargers vs. Colts game infoGame day: Sunday, October 19, 2025Game time: 4:05 p.m. ETTV channel: CBSLocation: Inglewood, CaliforniaStadium: SoFi StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)Live stream: Watch this game on Paramount+ (Regional restrictions may apply)

Watch Los Angeles Chargers vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)

Chargers vs. Colts odds & betting linesSpread favorite: Los Angeles (-1.5)Moneyline: Los Angeles (-129), Indianapolis (+108)Total: 48.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Chargers vs. Colts recent matchupsIn the last two meetings between the Chargers and Colts, Los Angeles has gone 2-0.Los Angeles outscored Indianapolis 50-27 in those two head-to-head matchups.Chargers vs. Colts betting insightsLos Angeles is 3-3-0 against the spread so far this season. In the five games this season the Chargers have been moneyline favorites, they have recorded a 3-2 record. Indianapolis has an against-the-spread record of 4-2-0 this season. The Colts have played a game as the underdog on the moneyline two times so far this season, and they split the two games.Chargers scoring insightsThe Chargers are averaging fewer points at home (20.0) than away (22.3).On defense, Los Angeles is conceding 22.7 points per game at home, more than its 19.0 average away from home.The Chargers have put up 23.3 points per game in the division, which is better than their average in non-division games of 19.0.Los Angeles has given up 16.7 points per game in the division, which is better than its average outside the division of 25.0.Over the Chargers’ most recent three-game stretch, they rank 26th in scoring offense (19.0 points per game) and 20th in scoring defense (25.0 points per game allowed).Colts scoring insightsAt home, the Colts’ scoring average is 33.3 points per game, which is better than their average away (30.5).On defense, Indianapolis concedes fewer points at home (17.3 per game) than away (23.5).The Colts are fourth-best in the league in points scored for the past three games (30.3 per game) and seventh in points conceded (20.0).Chargers injury reportChargers:
Derwin James: Full Participation in Practice (Rest),
Daiyan Henley: Limited Participation in Practice (Groin),
Troy Dye: Did Not Participate In Practice (Thumb),
Derius Davis: Limited Participation in Practice (Knee),
Joe Alt: Limited Participation in Practice (Ankle),
Keenan Allen: Full Participation in Practice (NIR – Rest),
Jamaree Salyer: Limited Participation in Practice (Knee),
Trey Pipkins: Did Not Participate In Practice (Knee),
Hassan Haskins: Full Participation in Practice (Chest),
Bradley Bozeman: Did Not Participate In Practice (Illness),
Denzel Perryman: Full Participation in Practice (Ankle),
Elijah Molden: Did Not Participate In Practice (Thumb),
Scott Matlock: Full Participation in Practice (Ankle),
Khalil Mack: Limited Participation in Practice (Elbow),
Kyle Kennard: Full Participation in Practice (Knee),
Quentin Johnston: Full Participation in Practice (Hamstring)Colts injury reportColts:
Charvarius Ward: Did Not Participate In Practice (Concussion),
Braden Smith: Full Participation in Practice (Rest),
Alec Pierce: Full Participation in Practice (Ankle),
Kenny Moore II: Limited Participation in Practice (Achilles),
Tyler Goodson: Did Not Participate In Practice (Groin),
Grover Stewart: Did Not Participate In Practice (Rest),
Ashton Dulin: Did Not Participate In Practice (Chest),
Josh Downs: Did Not Participate In Practice (Concussion)

Watch Los Angeles Chargers vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)