The New England Patriots (4-2) are expected to keep their three-game winning streak going as they are favored by a touchdown against the Tennessee Titans (1-5) on Sunday, October 19, 2025 at Nissan Stadium.

Patriots vs. Titans game infoGame day: Sunday, October 19, 2025Game time: 1 p.m. ETTV channel: CBSLocation: Nashville, TennesseeStadium: Nissan StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)Live stream: Watch this game on Paramount+ (Regional restrictions may apply)

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Patriots vs. Titans odds & betting linesSpread favorite: New England (-7)Moneyline: New England (-347), Tennessee (+275)Total: 42.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Patriots vs. Titans recent matchupsTennessee is 3-2 versus New England in the last five matchups between the two squads.New England put up 111 points in those five matchups, with Tennessee putting up 101.Patriots vs. Titans betting insightsNew England has four wins against the spread so far this season (4-2-0). The Patriots are 2-1 in the three games this season they have been the moneyline favorite. Tennessee, through six games with a set spread so far this season, has gone 2-4-0 against the spread. The Titans have been moneyline underdogs six times this year, going 1-5 in those games.Patriots scoring insightsThe Patriots are averaging fewer points at home (23.0) than away (27.0).On defense, New England’s average at home, 18.0 points conceded, is better than its average on the road, 22.0.While the Patriots rank fifth-best in scoring offense over the last three games (30.0 points per game), they’ve been less effective on the defensive side of the ball with 17.3 points allowed per game (sixth-ranked).Titans scoring insightsAt home, the Titans’ scoring average is 19.5 points per game, which is higher than their average on the road (11.0).On defense, Tennessee concedes more points at home (37.0 per game) than on the road (21.8).The Titans are worst in the NFL in points scored for the past three games (10.7 per game) and 12th in points conceded (22.3).Patriots injury reportPatriots:
Keion White: Full Participation in Practice (Elbow),
Christian Gonzalez: Full Participation in Practice (Hamstring),
Charles Woods: Did Not Participate In Practice (Knee),
Morgan Moses: Limited Participation in Practice (Hip),
Stefon Diggs: Limited Participation in Practice (Chest),
Christian Barmore: Full Participation in Practice (Nir – Other),
Marte Mapu: Limited Participation in Practice (Neck),
Harold Landry: Did Not Participate In Practice (Ankle),
Anfernee Jennings: Limited Participation in Practice (Ankle),
Jaylinn Hawkins: Limited Participation in Practice (Hamstring)Titans injury reportTitans:
Kevin Winston Jr.: Limited Participation in Practice (Hamstring),
T’Vondre Sweat: Limited Participation in Practice (Ankle),
L’Jarius Sneed: Limited Participation in Practice (Quadricep),
Joey Slye: Limited Participation in Practice (Calf),
Jeffery Simmons: Full Participation in Practice (NIR – Rest),
Dre’Mont Jones: Did Not Participate In Practice (Knee),
Calvin Ridley: Did Not Participate In Practice (Hamstring),
Bryce Oliver: Limited Participation in Practice (Knee),
James Lynch: Limited Participation in Practice (Shoulder),
Tyler Lockett: Full Participation in Practice (NIR – Rest),
Arden Key: Did Not Participate In Practice (Quadricep),
Van Jefferson: Limited Participation in Practice (Ankle),
Marcus Harris: Limited Participation in Practice (Calf),
Blake Hance: Limited Participation in Practice (Shoulder),
Kevin Zeitler: Full Participation in Practice (NIR – Rest)

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