The Los Angeles Chargers are 1.5-point favorites over the Indianapolis Colts in Week 7 of the 2025 regular season. The over/under is 48.5 points, per BetMGM Sportsbook.
That means oddsmakers are taking bets on whether the two teams will combine to score more than or fewer than 48.5 points.
My score prediction for the game is a 24-21 win for the Chargers, with a combined total of 45 points. So, if I were putting money based on my prediction, I’d bet the Under.
As for game picks, analysts are slightly leaning toward Indianapolis winning.
Nate Davis (USA Today): Colts
Jarrett Bell (USA Today): Chargers
Mike Clay (ESPN): Colts
Matt Bowen (ESPN): Colts
Pete Prisco (CBS Sports): Chargers
Bill Bender (Sporting News): Chargers
NFL.com Staff: Colts (4-1)
Bleacher Report: Colts (4-3)
Sunday’s game will begin at 1:05 p.m. PT and will be televised on CBS.