At SoFi Stadium on Sunday, Justin Herbert and the Los Angeles Chargers (4-2) face Jonathan Taylor and the Indianapolis Colts (5-1) in a matchup featuring a pair of outstanding runners, beginning at 4:05 p.m. ET.
The Chargers squared off against the Miami Dolphins in their last game, winning 29-27. The Colts’ last game was a 31-27 win over the Arizona Cardinals. Herbert threw for 264 yards, with two touchdowns and no interceptions on 29-of-38 passing (76.3%) for the Bolts in that matchup against the Dolphins. Kimani Vidal carried the ball 18 times for 124 yards (6.9 yards per carry). He also had three receptions for 14 yards and one touchdown. Ladd McConkey had seven receptions for 100 yards (14.3 per catch) and one touchdown against the Dolphins. Daniel Jones recorded 212 passing yards while going 22-for-30 with two touchdowns and one interception for the Colts against the Cardinals. He added five carries for 20 yards and one touchdown. Taylor carried the ball 21 times for 123 yards and one touchdown. He caught four passes for 14 yards. Tyler Warren recorded 63 yards through the air after six catches (on nine targets), with one touchdown.
See more coverage below, including how to watch this matchup on Fubo.
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Chargers vs. Colts game infoGame day: Sunday, October 19, 2025Game time: 4:05 p.m. ETLocation: Inglewood, CaliforniaStadium: SoFi StadiumTV channel: CBS (KBAK-Bakersfield, CA)Live stream: Fubo (Watch Now!)Live stream: Paramount+ (Watch Now!)
Watch Los Angeles Chargers vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)
Chargers vs. Colts betting info
NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 3:05 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Chargers (-1.5)Moneyline: Chargers (-130), Colts (+110)Total: 48.5 points
Watch Los Angeles Chargers vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)