On Sunday at 4:05 p.m. ET, two excellent runners will be on display when Justin Herbert and the Los Angeles Chargers (4-2) host Jonathan Taylor and the Indianapolis Colts (5-1).
The Colts’ defense ranks 19th in the NFL with 329.2 total yards surrendered per game, but they’ve been carried by their offense, which ranks fourth-best by piling up 376.8 total yards per game. The Chargers rank 23rd in scoring offense (21.2 points per game) and 12th in scoring defense (20.8 points allowed per game) this season.
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Colts vs Chargers: Live streaming info, TV channel & game timeGame day: Sunday, October 19, 2025Game time: 4:05 p.m. ETLocation: Inglewood, CaliforniaStadium: SoFi StadiumTV channel: CBSLive stream: Watch on Fubo! (Regional restrictions may apply)Live stream: Watch on Paramount+! (Regional restrictions may apply)
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Colts vs Chargers betting lines
NFL odds courtesy of BetMGM. Odds updated Saturday at 8:23 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Chargers (-1.5)Moneyline: Chargers (-128), Colts (+107)Total: 48.5 points
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