The Los Angeles Chargers (4-2) will play the Indianapolis Colts (5-1) on Sunday, October 19, 2025 at SoFi Stadium. The spread predicts a close game, with the Chargers favored by 1.5 points. The over/under in the outing is set at 48.5 points.
Facing the Miami Dolphins in their last contest, the Chargers won 29-27.
Against the Dolphins, Justin Herbert completed 29 of 38 attempts for 264 yards, with two touchdowns and no interceptions, for the Bolts.
The Colts beat the Arizona Cardinals, 31-27, in their last contest.
Chargers vs Colts betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 10:07 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Los Angeles (-1.5)Moneyline: Los Angeles (-128), Indianapolis (+108)Total: 48.5 pointsChargers betting insightsLos Angeles has two wins against the spread, and is 2-1 overall, at home this season.The Chargers have covered the spread in a matchup three times this season (3-3-0).At home, as 1.5-point favorites or greater, Los Angeles has one win ATS (1-1).In games they have played as 1.5-point favorites or more, the Chargers have an ATS record of 2-3.In three home games this season, Los Angeles has gone over the total once.Chargers games have gone over the total twice this season.Chargers leadersHerbert: 1,493 PASS YDS / 248.8 YPG / 67.6% / 10 TD / 4 INT / 24 CAR / 155 RUSH YDS / 0 TDKimani Vidal: 22 CAR / 142 YDS / 47.3 YPG / 0 TD / 4 REC / 15 YDS / 5.0 YPG / 1 TDQuentin Johnston: 26 REC / 377 YDS / 75.4 YPG / 4 TDKeenan Allen: 33 REC / 316 YDS / 52.7 YPG / 3 TDLadd McConkey: 28 REC / 313 YDS / 52.2 YPG / 2 TDChargers vs Colts game infoDate: Sunday, October 19, 2025Time: 4:05 p.m. ETCity: Inglewood, CaliforniaVenue: SoFi StadiumTV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Paramount+ (Regional restrictions may apply)
Watch Los Angeles Chargers vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)