The San Francisco 49ers (5-2) visit the Houston Texans (2-4) at NRG Stadium in Houston for a Week 8 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, October 26, including live updated odds and injury report news.

NameWeek 72025 RecordJon Hoefling10-558-47-3Blake Schuster9-655-50-3Tyler Dragon8-751-53-3Chris Bumbaca6-949-56-3Lorenzo Reyes10-550-55-3Jordan Mendoza8-739-37-2Richard MorinN/A16-12-1Texans vs. 49ers live odds, moneyline, over/under

Opening Lines

Spread: 49ers (-1.5)Moneyline: 49ers (-125), Texans (+105)Over/Under: 45.5

Get the edge with our exclusive NFL betting picks

Jon Hoefling: San Francisco 49ers (+1)

San Francisco has not looked good all year, but they keep finding ways to win games. Houston has also not looked good, but they are losing. The math isn’t hard here.

Jordan Mendoza: Houston Texans (-1)

Two teams going in opposite directions but expected to be a close one. This may be where Houston gets that signature win to finally get some real momentum.

Tyler Dragon: San Francisco 49ers (+1)

The 49ers have found ways to win despite a slew of injuries. Christian McCaffrey and George Kittle should lift San Francisco over the top.

Lorenzo Reyes: San Francisco 49ers (+1)

I love the Niners in this spot and think they should be the slight favorites. San Francisco is 3-1 against the spread on the road, and the Texans are far too undisciplined to back here.

Richard Morin: Houston Texans (-1)

Feels like we’re just waiting for the Texans to break out. Is this the week?

Christopher Bumbaca: Houston Texans (-1)

The Niners struggle coming off a win and the Texans’ defense could create problems for Brock Purdy if he’s healthy enough to start. Houston can’t be this bad and the injuries have to eventually catch up to San Francisco. Right?

Texans vs. 49ers updated injury reportNFL Week 8 picks, predictions odds

Vikings at Chargers | Dolphins at Falcons | Bears at Ravens | Browns at Patriots | Giants at Eagles | 49ers at Texans | Bills at Panthers | Jets at Bengals | Buccaneers at Saints | Titans at Colts | Cowboys at Broncos | Packers at Steelers | Commanders at Chiefs

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