The Indianapolis Colts (6-1) take a three-game winning streak into a matchup against the Tennessee Titans (1-6) on Sunday, October 26, 2025 at Lucas Oil Stadium. Indianapolis is favored by 14.5 points.

Colts vs. Titans game infoGame day: Sunday, October 26, 2025Game time: 4:25 p.m. ETTV channel: CBSLocation: Indianapolis, IndianaStadium: Lucas Oil StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)Live stream: Watch this game on Paramount+ (Regional restrictions may apply)

Watch Indianapolis Colts vs. Tennessee Titans on Fubo! (Regional restrictions may apply)

Colts vs. Titans odds & betting linesSpread favorite: Indianapolis (-14.5)Moneyline: Indianapolis (-1333), Tennessee (+810)Total: 47.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Colts vs. Titans recent matchupsIn the last five meetings between the Colts and Titans, Indianapolis has gone 5-0.The Colts have a 5-0 record against the spread in those games versus the Titans, and the two team outscored the point total on three occasions.Indianapolis scored 153 points in those five matchups, with Tennessee putting up 111.Colts vs. Titans betting insightsIndianapolis is 5-2-0 against the spread so far this season. The Colts have been the moneyline favorite four times this season, and they have gone 4-0 in those games. Tennessee, in seven games with a set spread so far this season, has gone 2-5-0 against the spread. The Titans’ record is 1-6 when playing as the underdog this year.Colts scoring insightsThe Colts are averaging more points at home (33.3) than on the road (33.0), but barely.Defensively, Indianapolis is giving up 17.3 points per game at home, better than its 23.7 average on the road.The Colts rank sixth in the NFL with 19.0 points per game allowed on defense over the last three contests, but they’ve really been thriving on the offensive side of the ball, as they rank best with 36.3 points per game during that period.Titans scoring insightsAt home, the Titans are averaging more points (17.3) than on the road (11.0).Defensively, Tennessee allows more points at home (35.0 per game) than on the road (21.8).In their past three games, the Titans are scoring 15.0 points per game (fourth-worst in NFL) and conceding 24.0 per game (19th).Colts injury reportColts:
Grover Stewart: Did Not Participate In Practice (NIR – Rest),
Braden Smith: Full Participation in Practice (NIR – Rest),
Kenny Moore II: Full Participation in Practice (Achilles),
Tyquan Lewis: Did Not Participate In Practice (Groin),
Jaylon Jones: Limited Participation in Practice (Hamstring),
Tyler Goodson: Full Participation in Practice (Groin),
Samson Ebukam: Did Not Participate In Practice (Knee),
Ashton Dulin: Full Participation in Practice ( Chest),
Josh Downs: Full Participation in Practice (Concussion)Titans injury reportTitans:
Sebastian Joseph-Day: Limited Participation in Practice (Calf),
Johnny Hekker: Full Participation in Practice (Illness),
Blake Hance: Did Not Participate In Practice (Shoulder),
Kevin Zeitler: Full Participation in Practice (NIR – Rest),
Xavier Woods: Limited Participation in Practice (Ankle),
Jihad Ward: Full Participation in Practice (NIR – Rest),
Jeffery Simmons: Did Not Participate In Practice (Hamstring),
Calvin Ridley: Did Not Participate In Practice (Hamstring),
Tony Pollard: Full Participation in Practice (NIR – Rest),
Bryce Oliver: Did Not Participate In Practice (Knee),
James Lynch: Limited Participation in Practice (Shoulder),
Arden Key: Limited Participation in Practice (Quadricep),
L’Jarius Sneed: Did Not Participate In Practice (Quadricep)

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