The Arizona Cardinals (2-3) visit the Indianapolis Colts (4-1) at Lucas Oil Stadium in Indianapolis for a Week 6 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, October 12, including live updated odds and injury report news.

Colts vs. Cardinals live odds, moneyline, over/under

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Colts vs. Cardinals picks against the spread

Jon Hoefling: Arizona Cardinals (+6.5)

Yes, the loss to Tennessee was bad, but a lot had to go wrong for Arizona in that game in order for it to happen. Such mishaps likely won’t happen again, and I’m banking on an Arizona bounce back effort.

Jordan Mendoza: Indianapolis Colts (-6.5)

The Cardinals really fumbled the end of last week, and that can happen when you have a thrilling team like Indianapolis on deck. The Colts show continues.

Tyler Dragon: Indianapolis Colts (-6.5)

The Cardinals are fresh off the worst home loss of the young season. The Colts have been the most surprising team of the NFL this year. Big advantage Indy.

Christopher Bumbaca: Indianapolis Colts (-6.5)

The Cardinals probably won’t have emotionally recovered from last week’s loss to the Tennessee Titans by the time this one kicks off. Don’t see the Colts’ biggest weakness (the secondary) having too many issues, either.

Lorenzo Reyes: Indianapolis Colts (-6.5)

The Colts have been one of the pleasant surprises in the league, and Daniel Jones is playing efficiently. Jonathan Taylor may have his hands full against a solid Arizona rush defense, but the Colts are the better pick here, even by a touchdown.

Blake Schuster: Indianapolis Colts (-6.5)

OK, fine. I’ll trust the Colts. Just this one time. Against an incredibly untrustworthy Cardinals team.

Colts vs. Cardinals updated injury reportNFL Week 6 picks, predictions oddsUSA TODAY NFL picks against the spread standingsNameWeek 52025 RecordBlake Schuster7-741-34-3Jon Hoefling7-740-35-3Tyler Dragon6-839-36-3Chris Bumbaca6-836-39-3Lorenzo Reyes5-835-40-3Jordan MendozaN/A24-22-2Richard Morin8-617-12-1Super Bowl 60 updated odds