The Houston Texans (2-4) are listed as close favorites (-2) against the San Francisco 49ers (5-2) on Sunday, October 26, 2025. The game’s total has been listed at 42 points.
Are you looking to make a parlay bet on this game? See insights, including team to score first and player prop bet insights, int the article below.
Texans vs. 49ers game odds
NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 7:41 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread: Texans -2 (-110 to cover)Moneylines: Texans -130, 49ers +110Total: 42 points (Over: -110, Under: -110)Pick ATS: Texans (-2)Pick OU: Under (42)Prediction:
Texans 21 – 49ers 18First TD odds and insights
First TD odds: Texans -120, 49ers -110
This season the Texans have scored the opening TD three times (in six games).Of Houston’s three first TDs, each came via a passing play.Looking at the first quarter only, the Texans have put two touchdowns on the board, 21st among all teams.The 49ers have scored the first TD five times this season out of seven games played.In those five games, one of San Francisco’s scores came on the ground, and four in the air.Looking at the first quarter only, the 49ers have put three touchdowns on the board, 13th among all teams.
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C.J. Stroud player propsPassing yard prop: Over/under 207.5 yardsRushing yard prop: Over/under 14.5 yardsC.J. Stroud has recorded 217.5 passing yards per game this season, 10.0 yards more than Sunday’s over/under.Stroud has gone over his passing yard totals two times this season (33.3% of total opportunities).Stroud has thrown for a touchdown five times this year in six games played, including multiple TD passes twice.Christian McCaffrey player propsRushing yard prop: Over/under 66.5 yardsReceiving yard prop: Over/under 43.5 yardsSunday’s rushing yards prop bet for Christian McCaffrey is set at 66.5 yards. That is 0.1 more than his season average of 66.4.McCaffrey has hit the over on his rushing yards total one time in seven opportunities this season.McCaffrey has a rushing touchdown in two games this year, including multiple rushing TDs once.Mac Jones player propsPassing yard prop: Over/under 225.5 yardsRushing yard prop: Over/under 7.5 yardsSunday’s passing yards over/under for Mac Jones is set at 225.5, 55.3 yards fewer than his season average of 280.8.Jones has hit the over on his passing yards prop bets twice this season.In three of five games this season, Jones has thrown a touchdown pass, including two games with multiple TD passes.