Check out best bets for when the Houston Texans (2-4) and the San Francisco 49ers (5-2) play at NRG Stadium on Sunday, October 26, 2025.
Watch Houston Texans vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
Best Texans vs. 49ers against the spread pickPick ATS: Texans (-2)Houston has covered the spread twice in six games this season.This season, the Texans have two against the spread wins in three games as a favorite of 2 points or more.In San Francisco’s seven games this season, it has four wins against the spread.The 49ers have been underdogs by 2 points or more two times this year and covered the spread once.Best Texans vs. 49ers over/under pickPick OU: Under (41.5)In two games this season, the Texans and their opponents have combined to total more than 41.5 points.The 49ers have played four games this season that ended with a point total higher than 41.5 points.These two teams score 41.9 points per game combined, 0.4 more than this game’s over/under.These two teams surrender a combined 34.4 points per game, 7.1 fewer points than this contest’s over/under.Best Texans vs. 49ers moneyline betMoneyline pick: Texans -130Based on this game’s moneyline, the Texans’ implied win probability is 56.5%.Houston has been the moneyline favorite three total times this season. They’ve finished 2-1 in those games.The Texans have a record of 2-1 when playing as a moneyline favorite with odds of -130 or shorter (66.7%).San Francisco has split the two games it has played as underdogs this season.This season, the 49ers have won one of their two games when they’re the underdog by at least +110 on the moneyline.How to watch Texans vs. 49ersWhen: Sunday, October 26, 2025 at 1 p.m. ETWhere: NRG Stadium in Houston, TexasTV info: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch Houston Texans vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)