Take a look at the injury report for the San Francisco 49ers (5-2), which has 16 players listed (including Christian McCaffrey), as the 49ers prepare for their matchup versus the Houston Texans (2-4) at NRG Stadium, on Sunday, Oct. 26 at 1 p.m. ET.
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49ers vs Texans TV channel & game infoGame day: Sunday, October 26, 2025Game time: 1 p.m. ETLocation: Houston, TexasStadium: NRG StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
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49ers injury reportBrock Purdy | QB (Out)Injury: ToePractice Status: Limited Participation in Practice2025 Passing: 73-for-48 | 586 Yards | 4 Touchdowns | 4 InterceptionsRicky Pearsall | WR (Out)Injury: KneePractice Status: Did Not Participate In Practice2025 Receiving Stats: 29 Targets | 20 Receptions | 327 Yards | 0 TouchdownsBryce Huff | DL (Out)Injury: HamstringPractice Status: Did Not Participate In Practice2025 Defensive Stats: 4.0 Sacks | 6.0 Tackles for Loss | 19 Tackles | 0 Interceptions | 1 Pass DefendedYetur Gross-Matos | DL (Out)Injury: KneePractice Status: Did Not Participate In PracticeJake Brendel | OL (Out)Injury: HamstringPractice Status: Did Not Participate In Practice2025 Season Stats: 3 Games PlayedDeommodore Lenoir | DB (Questionable)Injury: QuadricepPractice Status: Limited Participation in Practice2025 Defensive Stats: 0.0 Sacks | 3.0 Tackles for Loss | 26 Tackles | 0 Interceptions | 2 Passes DefendedLuke Gifford | LB (Questionable)Injury: HamstringPractice Status: Limited Participation in PracticeSpencer Burford | OL (Questionable)Injury: KneePractice Status: Limited Participation in PracticeTrent Williams | OTInjury: NIR – RestPractice Status: Full Participation in Practice2025 Season Stats: 3 Games PlayedCJ West | DTInjury: ThumbPractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 4 Tackles | 0 Interceptions | 0 Passes DefendedUpton Stout | CBInjury: AnklePractice Status: Full Participation in Practice2025 Defensive Stats: 1.0 Sack | 2.0 Tackles for Loss | 25 Tackles | 0 Interceptions | 2 Passes DefendedChristian McCaffrey | RBInjury: NIR – RestPractice Status: Full Participation in Practice2025 Rushing: 132 Attempts | 465 Yards | 3 Touchdowns2025 Receiving Stats: 68 Targets | 53 Receptions | 516 Yards | 3 TouchdownsMac Jones | QBInjury: KneePractice Status: Full Participation in Practice2025 Passing: 194-for-130 | 1,404 Yards | 6 Touchdowns | 4 Interceptions2025 Rushing: 21 Attempts | 34 Yards | 0 TouchdownsJauan Jennings | WRInjury: AnklePractice Status: Full Participation in Practice2025 Receiving Stats: 29 Targets | 14 Receptions | 167 Yards | 1 TouchdownRenardo Green | CBInjury: ToePractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 20 Tackles | 0 Interceptions | 5 Passes DefendedKalia Davis | DLInjury: HandPractice Status: Full Participation in Practice49ers insightsThe 49ers have scored slightly more points per game over their past three matchups (21.7) than they have averaged for the season (20.7).Turning our focus to yardage, San Francisco’s offense has seen a slight downtick in production over its last three games, amassing 364.7 total yards per game, compared to its season-long average of 366.6 yards per contest.In the passing game, the 49ers have seen a dip in production over their last three games, recording 259.7 passing yards per game, compared to their season-long average of 271.3 passing yards per contest.San Francisco has seen a slight uptick in production in the ground game over its last three matchups, rushing for 105.0 yards per contest, compared to its season-long average of 95.3 rushing yards per game.49ers vs Texans odds
NFL odds courtesy of BetMGM. Odds updated Saturday at 1:29 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Texans (-1.5)Moneyline: Texans (-130), 49ers (+110)Total: 42 points
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