The Houston Texans (2-4) will play the San Francisco 49ers (5-2) on Sunday, October 26, 2025 at NRG Stadium. The line foretells a close game, with the Texans favored by 2 points. The over/under is set at 42 in the outing.
The 49ers beat the Atlanta Falcons, 20-10, in their most recent game.
In that game versus the Falcons, Niners quarterback Mac Jones completed 17 of 26 passes for 152 yards, with no touchdowns and one interception.
Facing the Seattle Seahawks in their last contest, the Texans lost 27-19.
49ers vs Texans betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 4:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Houston (-2)Moneyline: Houston (-131), San Francisco (+110)Total: 42 points49ers betting insightsAway from home, San Francisco is 3-1 overall and 3-1 against the spread.The 49ers have put together a 4-3-0 record against the spread this year.San Francisco has one win ATS (1-1) as 2-point underdogs or more on the road.In games they have played as 2-point underdogs or more, the 49ers have an ATS record of 1-1.This season, in three of four road games San Francisco has hit the over.49ers games have finished with a final combined score above the over/under four times this season.49ers leadersJones: 1,404 PASS YDS / 280.8 YPG / 67% / 6 TD / 4 INTChristian McCaffrey: 132 CAR / 465 YDS / 66.4 YPG / 3 TD / 53 REC / 516 YDS / 73.7 YPG / 3 TDBrian Robinson Jr.: 36 CAR / 144 YDS / 20.6 YPG / 0 TD / 5 REC / 11 YDS / 1.6 YPG / 0 TDKendrick Bourne: 25 REC / 385 YDS / 64.2 YPG / 0 TDRicky Pearsall: 20 REC / 327 YDS / 81.8 YPG / 0 TD49ers vs Texans game infoDate: Sunday, October 26, 2025Time: 1 p.m. ETCity: Houston, TexasVenue: NRG StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)
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