One of the best runners in the league will be on display when James Cook and the Buffalo Bills (4-2) visit the Carolina Panthers (4-3) on Sunday, October 26, 2025.
In terms of total yards, the Panthers rank 19th in the NFL (326.7 total yards per game) and seventh on defense (295.7 total yards allowed per contest). The Bills rank 17th in scoring defense this year (22.8 points allowed per game), but they’ve been shining on offense, ranking fourth-best in the NFL with 27.8 points per game.
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Panthers vs Bills: Live streaming info, TV channel & game timeGame day: Sunday, October 26, 2025Game time: 1 p.m. ETLocation: Charlotte, North CarolinaStadium: Bank of America StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch Buffalo Bills vs. Carolina Panthers on Fubo! (Regional restrictions may apply)
Panthers vs Bills betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 12:23 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Bills (-7.5)Moneyline: Bills (-400), Panthers (+313)Total: 46.5 points
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