Jonathan Taylor will lead the Indianapolis Colts (6-1) into their battle against the Tennessee Titans (1-6) at Lucas Oil Stadium on Sunday at 4:25 p.m. ET.
The Colts sport the 22nd-ranked defense this year (345.7 yards allowed per game), and they’ve been more effective on offense, ranking second-best with 380.3 yards per game. This season has been hard for the Titans on both offense and defense, as they are posting just 13.7 points per contest (worst) and allowing 27.4 points per game (fifth-worst).
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Colts vs Titans: live streaming info, TV channel & game timeGame day: Sunday, October 26, 2025Game time: 4:25 p.m. ETLocation: Indianapolis, IndianaStadium: Lucas Oil StadiumTV channel: CBSLive stream: Watch on Fubo! (Regional restrictions may apply)Live stream: Watch on Paramount+! (Regional restrictions may apply)
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Colts vs Titans betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 12:15 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Colts (-14.5)Moneyline: Colts (-1408), Titans (+830)Total: 48 points
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