One of the best runners in the NFL will be on display when Christian McCaffrey and the San Francisco 49ers (5-2) visit the Houston Texans (2-4) on Sunday, October 26, 2025.
The Texans rank 21st in points scored this year (21.2 points per game), but they’ve been thriving on the other side of the ball, ranking best in the NFL with 14.7 points allowed per game. With 20.7 points per game on offense, the 49ers rank 23rd in the NFL. On defense, they rank seventh, allowing 19.7 points per game.
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Texans vs 49ers: live streaming info, TV channel & game timeGame day: Sunday, October 26, 2025Game time: 1 p.m. ETLocation: Houston, TexasStadium: NRG StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch Houston Texans vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
Texans vs 49ers betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 12:15 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Texans (-2.5)Moneyline: Texans (-133), 49ers (+112)Total: 42 points
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