The Houston Texans (2-4) will play the San Francisco 49ers (5-2) on Sunday, October 26, 2025 at NRG Stadium. The spread foretells a close game, with the Texans favored by 2.5 points. An over/under of 42 points has been set for the outing.
Against the Seattle Seahawks in their last contest, the Texans lost 27-19.
Against the Seahawks, C.J. Stroud completed 23 of 49 attempts for 229 yards, with one touchdown and one interception, for the Texans.
Against the Atlanta Falcons in their most recent game, the 49ers won 20-10.
Texans vs 49ers betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 12:03 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Houston (-2.5)Moneyline: Houston (-133), San Francisco (+112)Total: 42 pointsTexans betting insightsHouston was 3-4-1 against the spread, and 5-3 overall, at home last season.The Texans are 2-4-0 against the spread this season.At home last year, as 2.5-point favorites or greater, Houston had one win ATS (1-3-1).The Texans are 2-1 ATS when playing as at least 2.5-point favorites.In eight home games last year, Houston went over the total once.Texans games have gone over the total twice this season.Texans leadersStroud: 1,305 PASS YDS / 217.5 YPG / 64.8% / 9 TD / 4 INT / 20 CAR / 147 RUSH YDS / 0 TDNick Chubb: 63 CAR / 265 YDS / 44.2 YPG / 2 TD / 8 REC / 41 YDS / 6.8 YPG / 0 TDWoody Marks: 46 CAR / 152 YDS / 25.3 YPG / 1 TD / 9 REC / 116 YDS / 19.3 YPG / 2 TDNico Collins: 26 REC / 339 YDS / 56.5 YPG / 3 TDDalton Schultz: 30 REC / 284 YDS / 47.3 YPG / 0 TDXavier Hutchinson: 13 REC / 123 YDS / 20.5 YPG / 2 TDTexans vs 49ers game infoDate: Sunday, October 26, 2025Time: 1 p.m. ETCity: Houston, TexasVenue: NRG StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)
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