James Cook will lead the Buffalo Bills (4-2) into their game against the Carolina Panthers (4-3) at Bank of America Stadium on Sunday at 1 p.m. ET.
On the offensive side of the ball, the Bills have been a top-five unit, ranking fourth-best in the NFL by putting up 27.8 points per game. They rank 17th on defense (22.8 points allowed per game). In terms of points scored the Panthers rank 23rd in the NFL (20.7 points per game), and they are 13th defensively (21.7 points allowed per contest).
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Bills vs Panthers: live streaming info, TV channel & game timeGame day: Sunday, October 26, 2025Game time: 1 p.m. ETLocation: Charlotte, North CarolinaStadium: Bank of America StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch Buffalo Bills vs. Carolina Panthers on Fubo! (Regional restrictions may apply)
Bills vs Panthers betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 4:22 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Bills (-7.5)Moneyline: Bills (-400), Panthers (+313)Total: 46.5 points
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