What to KnowProgramming note: Before the 49ers play the Texans, tune into “49ers Pregame Live” at 9 a.m. PT on NBC Sports Bay Area or stream the show in the NBC Sports app for a full game preview with Carlos Ramírez, Rod Brooks and Matt Maiocco.The San Francisco 49ers (5-2) seek a second consecutive win in their Week 8 game against the Houston Texans (2-4) on Sunday at NRG Stadium.Mac Jones makes his sixth start of the 2025 NFL season at quarterback and fourth in a row as Brock Purdy misses another game with a lingering turf toe injury, while wide receiver Ricky Pearsall (knee) is not suiting up for a fourth straight game.Texans quarterback C.J. Stroud is without his top two receivers for the game, after Houston ruled out Nico Collins (concussion) and Christian Kirk (hamstring).San Francisco is playing against a familiar face in Houston coach DeMeco Ryans, who spent six seasons on the 49ers’ coaching staff and two as the team’s defensive coordinator from 2017-2022.Insider Matt Maiocco listed his five 49ers players to watch before San Francisco takes on Ryans and the Texans’ vaunted defense.Programming note: Immediately after the Week 16 game ends, watch “49ers Postgame Live” on NBC Sports Bay Area or stream the show in the NBC Sports app for full reaction, analysis and interviews.
Follow this live blog for the latest score updates, game highlights, news and analysis from NRG Stadium in Houston: